Diabetes　is　an　important　public　health　problem　and　finding　quick　testing　methods　with　high　accuracy,　reliability,　and　convenience　are　important　to　control　the　blood　glucose　of　diabetic　patients.　In　this　study,　a　sensor　based　on　a　weak　measurement　scheme　was　developed　for　the　specific　detection　of　glucose　for　the　first　time.　The　detection　of　glucose　using　the　proposed　method　was　completed　by　the　high　sensitivity　and　resolution　of　the　weak　measurement　based　on　optical　rotation　detection,　as　well　as　the　change　in　the　optical　rotation　before　and　after　the　specific　oxidation　of　glucose.　The　resolution　of　the　as-obtained　glucose　sensor　was　around　2.71×10-3　g/L　(1.50×10-2　mmol/L),　and　the　detection　range　was　0-11　g/L　(0-61　mmol/L).　©　2021　Optical　Society　of　America.