In　recent　years,　the　developed　hemostatic　technologies　are　still　difficult　to　be　applied　to　the　hemostasis　of　massive　arterial　and　visceral　hemorrhage,　owing　to　their　weak　hemostatic　function,　inferior　wet　tissue　adhesion,　and　low　mechanical　properties.　Herein,　a　mussel-inspired　supramolecular　interaction-cross-linked　hydrogel　with　robust　mechanical　property　(308.47　+/-　29.20　kPa)　and　excellent　hemostatic　efficiency　(96.5%　+/-　2.1%)　was　constructed　as　a　hemostatic　sealant.　Typically,　we　combined　chitosan　(CS)　with　silk　fibmin　(SF)　by　cross-linking　them　through　tannic　acid　(TA)　to　maintain　the　structural　stability　of　the　hydrogel,　especially　for　wet　tissue　adhesion　ability　(shear　adhesive　strength　=　29.66　+/-　0.36　kPa).　Compared　with　other　materials　reported　previously,　the　obtained　CS/TA/SF　hydrogel　yielded　a　lower　amount　of　blood　loss　and　shorter　time　to　hemostasis　in　various　arterial　and　visceral　bleeding　models,　which　could　be　ascribed　to　the　synergistic　effect　of　wound　closure　under　wet　state　as　well　as　intrinsic　hemostatic　activity　of　CS.　As　a　superior　hemostatic　sealant,　the　unique　hydrogel　proposed　in　this　work　can　be　exploited　to　offer　significant　advantages　in　the　acute　wound　and　massive　hemorrhage　with　the　restrictive　access　of　therapeutic　moieties.