Query：
学者姓名：张进
Refining：
Year
Type
Indexed by
Source
Complex
Former Name
Co-
Language
Clean All
Abstract ：
Critical-sized bone defects caused by trauma, congenital malformation, or tumor resection remain a major challenge around the world. Current bone tissue-engineering scaffolds are partially confined by inadequate scaffold architecture design that mismatches with natural bone tissue, which affect normal biological functions like inflammation modulation and biomineralization, thus impairing bone regeneration process. Herein, a biomimetic 3D-printed BMGP scaffold composed of polydopamine (PDA)-polylactide (PLA) scaffold and black phosphorus (BP) nanosheets/manganese carbonyl (MnCO) nanosheets/gelatin methacryloyl hydrogel (named as BMG hydrogel) was developed for augmenting bone regeneration via strengthening anti-inflammatory effect and promoting in-situ biomineralization process. Through infilling the BMG hydrogel into the gradient-porous PDA-PLA scaffold, the obtained BMGP scaffold successfully mimicked cancellous and compact bone structure and extracellular matrix component in natural bone tissue. Upon being implanted into the critical-sized bone defect, a Fenton-like reaction between the MnCO nanosheet and endogenous hydrogen peroxide effectively induced carbon monoxide release, thereby improving anti-inflammatory response and facilitating macrophage reversed from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype. Meanwhile, the BP nanosheet underwent degradation and in-situ biomineralization, which accelerated calcium phosphate formation and enhanced osteogenesis. Based on in-vitro and in-vivo data, the 3D-printed BMGP scaffold that integrated structural and functional biomimicry exhibited desirable inflammatory inhibition and in-situ biomineralization performances, as well as favorable osteogenic effect in rat critical-sized femoral bone defect. In all, such biomimetic scaffold obviously propelled bone regeneration process, and provided a promising strategy for treating critical-sized bone defects in clinic.
Keyword ：
3D-printing 3D-printing Biomimetic tissue engineering scaffold Biomimetic tissue engineering scaffold Bone regeneration Bone regeneration Inflammation inhibition Inflammation inhibition In-situ biomineralization In-situ biomineralization
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Wu, Dongyu , Gao, Shangjun , He, Shaohua et al. 3D-printed scaffold with biomimetic gradient structure for promoting bone regeneration through inhibiting inflammation and facilitating in-situ biomineralization [J]. | BIOMATERIALS ADVANCES , 2026 , 178 . |
| MLA | Wu, Dongyu et al. "3D-printed scaffold with biomimetic gradient structure for promoting bone regeneration through inhibiting inflammation and facilitating in-situ biomineralization" . | BIOMATERIALS ADVANCES 178 (2026) . |
| APA | Wu, Dongyu , Gao, Shangjun , He, Shaohua , Liu, Wanling , Liu, Qingwei , Lan, Siyao et al. 3D-printed scaffold with biomimetic gradient structure for promoting bone regeneration through inhibiting inflammation and facilitating in-situ biomineralization . | BIOMATERIALS ADVANCES , 2026 , 178 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Osteosarcoma (OS) is a highly aggressive and lethal malignant tumor with a 5-year overall survival rate of less than 20%, while its post-operative recovery remains suboptimal due to persistent inflammatory responses, incomplete clearance of residual tumor cells, and insufficient repair of tumor-induced large bone defects. Herein, a self-adaptive multi-functional RPSH hydrogel is successfully prepared by integrating a self-assembled 1-bromoacetyl-3,3-dinitroazetidine (RRx-001)/indocyanine green (ICG)@diselenide nanoparticle (R/I@SeNP) into a dual-network polyacrylamide/sodium alginate/hyaluronic acid (PAAm/SA/HA) hydrogel matrix. Initially, high molecular weight HA effectively suppresses the NF-kappa B pathway and induces macrophage polarization toward the M2 phenotype within 24 h, thereby reversing inflammatory microenvironments following OS resection. Then, dual-responsive R/I@SeNP enables a multi-modal anti-cancer approach by up-regulating levels of reactive oxygen/nitrogen species and generating RSeH or the immune checkpoint inhibitor RSeO(OH) with a tumor growth inhibition rate of 72.84% +/- 6.75% at three weeks post-surgery. Remarkably, the RPSH hydrogel promotes substantial new-bone formation and achieves a bone volume/total tissue volume (BV/TV) ratio of 59.03% +/- 9.41% following eight weeks of implantation by regulating the osteogenic-osteoclastic balance, demonstrating its sustained ability to create microenvironments favorable for bone regeneration. This self-adaptive hydrogel-based strategy offers promising insights and potential benefits for improving post-operative OS therapy.
Keyword ：
inflammation resolution inflammation resolution multi-modal tumor inhibition multi-modal tumor inhibition osteogenesis osteogenesis osteosarcoma treatment osteosarcoma treatment self-adaptive hydrogel self-adaptive hydrogel
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Lin, Hairong , Jin, Xinmeng , Cao, Yang et al. Self-Adaptive Hydrogel with Cascade Microenvironments-Responsiveness to Inhibit Osteosarcoma Progression and Augment Bone Reconstruction [J]. | ADVANCED FUNCTIONAL MATERIALS , 2025 . |
| MLA | Lin, Hairong et al. "Self-Adaptive Hydrogel with Cascade Microenvironments-Responsiveness to Inhibit Osteosarcoma Progression and Augment Bone Reconstruction" . | ADVANCED FUNCTIONAL MATERIALS (2025) . |
| APA | Lin, Hairong , Jin, Xinmeng , Cao, Yang , Ruan, Renjie , Liu, Changhua , Huang, Shandeng et al. Self-Adaptive Hydrogel with Cascade Microenvironments-Responsiveness to Inhibit Osteosarcoma Progression and Augment Bone Reconstruction . | ADVANCED FUNCTIONAL MATERIALS , 2025 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Although central venous catheters (CVCs) exhibit promising hemocompatibility and interfacial stability, their clinical applications are constrained by the inability to counteract thrombus and acute inflammation. Herein, a novel vascular intima-biomimetic bilayered hydrogel coating is designed to mitigate clinical thrombotic and inflammatory complications. Firstly, passive anti-coagulation shield established by hydrophilic groups orchestrated robust hydration shells, which achieved non-specific adhesion resistance against blood compositions. Active anti-coagulation mode was simultaneously established by dynamic thiol/sulfonic redox moieties, realizing synergetic inhibition effects on the activity of coagulation factors and self-activation of coagulation cascade. Secondly, the hydrogel presented a free radicals-scavenging rate of 79.42% ± 1.34% coupled with macrophage phenotype remodeling, effectively constructing an ideal anti-bacterial microenvironment for repair of oxidative stress-mediated endothelial damage. More interestingly, such biomimetic bilayered hydrogel coating achieved exceptional adhesion stability toward CVCs, meanwhile its vascular intima-mimetic modulus reduced mismatch-induced endothelial injury, thereby ensuring long-term interfacial integrity and implant safety. According to in vivo and ex vivo results of rat subcutaneous implantation and rabbit arteriovenous (AV) shunts model, the coating significantly decreased catheter occlusion rate (0.90% ± 0.64%), suppressed F1+2 accumulation, and inhibited TNF-α expression. Overall, the hydrogel coating with synergetic anti-coagulant/anti-inflammatory functionalities established an effective bio-interfacial for clinical indwelling device safety, demonstrating particularly promising applications. © 2025 Wiley-VCH GmbH.
Keyword ：
active/passive·anti-coagulation active/passive·anti-coagulation bilayer hydrogel coating bilayer hydrogel coating dynamic anti-inflammation dynamic anti-inflammation strong interfacial adhesion strong interfacial adhesion vascular intima-biomimetic vascular intima-biomimetic
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Hu, X. , Mou, X. , Pan, G. et al. Vascular Intima-Biomimetic Bilayer Hydrogel Coating of Central Venous Catheters with Dual-Modal Anti-Coagulation and Self-Adaptive Immunomodulation [J]. | Advanced Functional Materials , 2025 . |
| MLA | Hu, X. et al. "Vascular Intima-Biomimetic Bilayer Hydrogel Coating of Central Venous Catheters with Dual-Modal Anti-Coagulation and Self-Adaptive Immunomodulation" . | Advanced Functional Materials (2025) . |
| APA | Hu, X. , Mou, X. , Pan, G. , Liu, Y. , Song, W. , Xiao, P. et al. Vascular Intima-Biomimetic Bilayer Hydrogel Coating of Central Venous Catheters with Dual-Modal Anti-Coagulation and Self-Adaptive Immunomodulation . | Advanced Functional Materials , 2025 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Critical-sized bone defects present a clinical challenge due to their limited self-repair capacity. Application of bone tissue-engineering scaffolds often overlooks the dynamic modulation of the microenvironment, resulting in unsatisfactory bone-regeneration outcomes. In this study, a bone morphogenetic protein-2-derived peptide-loaded honeycomb manganese dioxide (BHM) nanozyme was incorporated into a composite hydrogel (BHM@CG) composed of l-arginine-modified methacrylated carboxymethyl chitosan and gallic acid-grafted methacrylated gelatin. This hydrogel demonstrated a cascade-regulated enhancement of hemostasis, antibacterial activity, anti-inflammatory effects, and osteogenesis. Initially, the BHM@CG hydrogel achieved rapid hemostasis by quickly adhering to irregular defects upon injury. Subsequently, it displayed robust antibacterial activity through synergistic hydrogen bonding, hydrophobic interactions, and cationic interactions. Meanwhile, the BHM nanozyme and polyphenol groups from gallic acid effectively eliminated reactive oxygen species, enabling long-term inflammation regulation. Finally, sustained release of bioactive components promoted cell migration, angiogenesis, and osteogenesis, achieving a bone-formation rate of nearly 40% in a critical-sized calvarial defect model by week 8. More interestingly, the hydrogel also demonstrated efficient antibacterial and bone-regeneration capabilities in an infected critical-sized calvarial defect model. Overall, this hydrogel dynamically modulated the bone-defect microenvironment and effectively enhanced bone regeneration, offering a promising strategy for critical-sized bone-defect repair.
Keyword ：
bone regeneration bone regeneration cascade-regulation cascade-regulation hemostasis hemostasis inflammation resolution inflammation resolution nanozyme nanozyme
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Chen, Jiaxin , Zhao, Ye , Ruan, Renjie et al. Bone Morphogenetic Protein-2-Derived Peptide-Conjugated Nanozyme-Integrated Photoenhanced Hybrid Hydrogel for Cascade-Regulated Bone Regeneration [J]. | ACS NANO , 2025 , 19 (15) : 14707-14726 . |
| MLA | Chen, Jiaxin et al. "Bone Morphogenetic Protein-2-Derived Peptide-Conjugated Nanozyme-Integrated Photoenhanced Hybrid Hydrogel for Cascade-Regulated Bone Regeneration" . | ACS NANO 19 . 15 (2025) : 14707-14726 . |
| APA | Chen, Jiaxin , Zhao, Ye , Ruan, Renjie , Feng, Xiao , Niu, Zexuan , Pan, Lei et al. Bone Morphogenetic Protein-2-Derived Peptide-Conjugated Nanozyme-Integrated Photoenhanced Hybrid Hydrogel for Cascade-Regulated Bone Regeneration . | ACS NANO , 2025 , 19 (15) , 14707-14726 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
It is highly desirable but still remains challenging to develop high-performance hydrogels with satisfactory mechanical properties for tissue engineering. Here, anisotropic yet transparent hydrogels (AHs) are prepared for tendon repair via a facile "poor solvent evaporation assisted hot-stretching" strategy. AHs have great mechanical properties with tensile strength, toughness, and fracture energy as high as 33.14 +/- 2.05 MPa, 44.1 +/- 3.5 MJ m(-3), and 106.18 +/- 7.2 kJ m(-2), respectively. Especially, AHs show unique flaw-insensitive characteristics, and cracks can only deflect along the fiber alignment direction rather than propagate transverse to this direction, showing an interesting self-protection function. The high strength, toughness, and fatigue resistance originate from the hierarchal structure of AHs, i.e., the densified polymeric network comprising fiber bundles and nanofibrils with aligned macromolecular chains, crystalline domains, and intermolecular hydrogen bonds. AHs with superior biocompatibility and swelling resistance can be used to repair rat tendons, and implantation of AHs can promote collagen regeneration for the tendon repair. This study provides a new method to fabricate strong and anti-fatigue hydrogels as a new class of promising materials for soft tissues.
Keyword ：
anisotropic hydrogels anisotropic hydrogels flaw-insensitivity flaw-insensitivity hot-stretching hot-stretching poor solvent evaporation poor solvent evaporation tendon repair tendon repair
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Li, Huamin , Zhang, Ying , Wu, Haidi et al. Strong and Fatigue-Resistant Hydrogels via Poor Solvent Evaporation Assisted Hot-Stretching for Tendon Repair [J]. | ADVANCED SCIENCE , 2025 , 12 (28) . |
| MLA | Li, Huamin et al. "Strong and Fatigue-Resistant Hydrogels via Poor Solvent Evaporation Assisted Hot-Stretching for Tendon Repair" . | ADVANCED SCIENCE 12 . 28 (2025) . |
| APA | Li, Huamin , Zhang, Ying , Wu, Haidi , Liu, Zhanqi , Guan, Cheng , Zhang, Jin et al. Strong and Fatigue-Resistant Hydrogels via Poor Solvent Evaporation Assisted Hot-Stretching for Tendon Repair . | ADVANCED SCIENCE , 2025 , 12 (28) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Healing of chronic wounds becomes a global health issue due to increasing incidence and associated burdens, and therefore promoting tissue-remodeling and monitoring wound-status visually are of particular significance. Herein, an electronic-skin patch (TENG-gel) composed by polydimethylsiloxane/polytetrafluoroethylene film, eutectic gallium-indium (E-GaIn), and quaternary chitosan/polyacrylamide/sodium alginate@molybdenum disulfide (MoS2) nanosheet (H-QPS@MoS2) composite hydrogel is assembled layer-by-layer. First, the TENG-gel realizes multimodal antibacterial by integrating peroxidase-like activity, photothermal therapy, and nano-knife effect, which eliminates both Gram-positive/negative bacteria with killing ratio of above 95%. Besides, electrical stimulation generated from the TENG-gel promotes migration of fibroblasts after an incubation of 48 h by activating signaling pathways, and meanwhile accelerates vascularization by secreting different growth factors of CD31, VEGF, and TGF-beta. Through providing an ideal microenvironment for tissue repair, the TENG-gel achieves 1.6-fold new hair follicles and 2.4-fold collagen deposition compared with those of the control group. More interestingly, dual temperature-/strain-sensing performance enables the TENG-gel with capability of monitoring wound status or reminding external danger signals in real-time dependent on variational electrical signals. Overall, unique advantages of such smart electronic-skin patch provide a personalized medicine strategy for realizing tissue reconstruction and monitoring synchronously.
Keyword ：
chronic wounds chronic wounds MoS2 nanosheets MoS2 nanosheets multimodal antibacterial multimodal antibacterial real-time monitoring real-time monitoring wireless self-powered wireless self-powered
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Liu, Wanling , Ye, Juncheng , Wang, Yanlang et al. Multimodal Antibacterial E-Skin Patch Driven by Oxidative Stress for Real-Time Wound-Status Monitoring and Integrated Treatment of Chronic Wounds [J]. | ADVANCED FUNCTIONAL MATERIALS , 2025 , 35 (22) . |
| MLA | Liu, Wanling et al. "Multimodal Antibacterial E-Skin Patch Driven by Oxidative Stress for Real-Time Wound-Status Monitoring and Integrated Treatment of Chronic Wounds" . | ADVANCED FUNCTIONAL MATERIALS 35 . 22 (2025) . |
| APA | Liu, Wanling , Ye, Juncheng , Wang, Yanlang , Xu, Xiaobo , Gao, Yujie , Liu, Kangyu et al. Multimodal Antibacterial E-Skin Patch Driven by Oxidative Stress for Real-Time Wound-Status Monitoring and Integrated Treatment of Chronic Wounds . | ADVANCED FUNCTIONAL MATERIALS , 2025 , 35 (22) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Traditional hepatocellular carcinoma-chip models lack the cell structure and microenvironments necessary for high pathophysiological correlation, leading to low accuracy in predicting drug efficacy and high production costs. This study proposed a decellularized hepatocellular carcinoma-on-a-chip model to screen anti-tumor nanomedicine. In this model, human hepatocellular carcinoma (HepG2) and human normal liver cells (L02) were co-cultured on a three-dimensional (3D) decellularized extracellular matrix (dECM) in vitro to mimic the tumor microenvironments of human hepatocellular carcinoma in vivo. Additionally, a smart nanomedicine was developed by encapsulating doxorubicin (DOX) into the ferric oxide (Fe3O4)-incorporated liposome nanovesicle (NLV/Fe+DOX). NLV/Fe+DOX selectively killed 78.59% +/- 6.78% of HepG2 cells through targeted delivery and synergistic chemo-chemodynamic-photothermal therapies, while the viability of surrounding L02 cells on the chip model retained high, at over 90.0%. The drug efficacy tested using this unique chip model correlated well with the results of cellular and animal experiments. In summary, our proposed hepatocellular carcinoma-chip model is a low-cost yet accurate drug-testing platform with significant potential for drug screening.
Keyword ：
Decellularized extracellular matrix Decellularized extracellular matrix Drug screening Drug screening Hepatocellular carcinoma-on-a-chip model Hepatocellular carcinoma-on-a-chip model Multi-functional nanomedicine Multi-functional nanomedicine Synergistic tumor therapy Synergistic tumor therapy
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Chen, Yueqing , Lin, Genhui , Wang, Ziyi et al. Predicting anti-tumor efficacy of multi-functional nanomedicine on decellularized hepatocellular carcinoma-on-a-chip [J]. | BIOSENSORS & BIOELECTRONICS , 2024 , 264 . |
| MLA | Chen, Yueqing et al. "Predicting anti-tumor efficacy of multi-functional nanomedicine on decellularized hepatocellular carcinoma-on-a-chip" . | BIOSENSORS & BIOELECTRONICS 264 (2024) . |
| APA | Chen, Yueqing , Lin, Genhui , Wang, Ziyi , He, Jingjing , Yang, Guanqing , Lin, Zhe et al. Predicting anti-tumor efficacy of multi-functional nanomedicine on decellularized hepatocellular carcinoma-on-a-chip . | BIOSENSORS & BIOELECTRONICS , 2024 , 264 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Stimuli-triggered release and alleviating resistance of iridium(III)-based drugs at tumor sites remains challengeable for clinical hepatoma therapy. Herein, a doxorubicin@iridium-transferrin (DOX@IrTF) nanovesicle was synthesized by carboxylated-transferrin (TF) and doxorubicin-loaded amphiphilic iridium-amino with quaternary ammonium (QA) groups and disulfide bonds. The QA groups enhanced photophysical properties and broadened production capacity of photoinduced-reactive oxygen species (ROS), while the disulfide-bridged bonds regulated oxidative stress levels through reacting with glutathione (GSH); simultaneously, modification of TF improved recognition and endocytosis of the nanovesicle for tumor cells. Based on in -vitro results, a controlled-release behavior of DOX upon a dualresponsiveness of GSH and near-infrared ray (NIR) irradiation was presented, along with high-efficiency generation of ROS. After an intravenous injection, the nanovesicle was targeted at tumor sites, realizing TF-navigated photoacoustic imaging guidance and synergistic chemotherapy-photodynamic therapy under NIR/GSH stimulations. Overall, newly-synthesized DOX@Ir-TF nanovesicle provided a potential in subcutaneous hepatocellular carcinoma therapy due to integrations of targeting delivery, dual -stimuli responsive release, synergistic therapy strategy, and real -time monitoring. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
Keyword ：
Amphiphilic iridium complex Amphiphilic iridium complex NIR/GSH dual-responsiveness NIR/GSH dual-responsiveness Photoacoustic imaging Photoacoustic imaging Synergistic tumor therapy Synergistic tumor therapy Transferrin targeting Transferrin targeting
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Guo, Jinyu , Lin, Yandai , He, Shaohua et al. Utilizing dual-responsive iridium(III) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy [J]. | CHINESE CHEMICAL LETTERS , 2024 , 35 (9) . |
| MLA | Guo, Jinyu et al. "Utilizing dual-responsive iridium(III) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy" . | CHINESE CHEMICAL LETTERS 35 . 9 (2024) . |
| APA | Guo, Jinyu , Lin, Yandai , He, Shaohua , Chen, Yueqing , Li, Fenglu , Ruan, Renjie et al. Utilizing dual-responsive iridium(III) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy . | CHINESE CHEMICAL LETTERS , 2024 , 35 (9) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Besides their limited preservation capacity and low biosafety, traditional fruit preservation procedures exacerbate "white pollution" because they utilize excessive plastic. Herein, an environmentally friendly one-pot method was developed to obtain degradable polyvinyl alcohol (PVA), where the hydroxyl radicals generated through the reaction between hydrogen peroxide (H2O2) and iron ions functioned to oxidize PVA. The oxidized PVA (OPVA-1.0) with abundant ketone groups, reduced crystallinity, and short molecular chains was completely degraded into H2O and CO2 after being buried in the soil for similar to 60 days. An improvement in its degradation rate did not weaken the mechanical properties of OPVA-1.0 compared to other modified PVA films because the adverse effect of decreased crystallinity on its mechanical performance was offset by its ion coordination. Alternatively, the tensile strength or toughness of OPVA-1.0 was enhanced due to its internal multi-level interactions including molecular chain entanglement, hydrogen bonding, and metal coordination bonds. More interestingly, OPVA-1.0 was water-welded into various products in a recyclable way owing to its reversible physical bonds, where it was sprayed, dipped, or brushed conformally onto different perishable fruits to delay their ripening by 5-14 days. Based on the cellular biocompatibility and biosafety evaluations in mice, OPVA-1.0 obtained by the facile oxidation strategy was demonstrated to alleviate "white pollution" and delay the ripening of fruits effectively. Oxidized PVA (OPVA-1.0) obtained by one-pot method is completely degraded in soil, which is further sprayed, dipped, or brushed conformally onto different perishable fruits to delay the ripening by 5-14 days as ideal packaging materials.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Lu, Yi , Liu, Guoming , Zhang, Kaixin et al. Sprayable oxidized polyvinyl alcohol with improved degradability and sufficient mechanical property for fruit preservation [J]. | JOURNAL OF MATERIALS CHEMISTRY B , 2024 , 12 (35) : 8716-8732 . |
| MLA | Lu, Yi et al. "Sprayable oxidized polyvinyl alcohol with improved degradability and sufficient mechanical property for fruit preservation" . | JOURNAL OF MATERIALS CHEMISTRY B 12 . 35 (2024) : 8716-8732 . |
| APA | Lu, Yi , Liu, Guoming , Zhang, Kaixin , Wang, Ziyi , Xiao, Peijie , Liu, Changhua et al. Sprayable oxidized polyvinyl alcohol with improved degradability and sufficient mechanical property for fruit preservation . | JOURNAL OF MATERIALS CHEMISTRY B , 2024 , 12 (35) , 8716-8732 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Stimuli-triggered release and alleviating resistance of iridium(Ⅲ)-based drugs at tumor sites re-mains challengeable for clinical hepatoma therapy.Herein,a doxorubicin@iridium-transferrin(DOX@Ir-TF)nanovesicle was synthesized by carboxylated-transferrin(TF)and doxorubicin-loaded amphiphilic iridium-amino with quaternary ammonium(QA)groups and disulfide bonds.The QA groups enhanced photophysical properties and broadened production capacity of photoinduced-reactive oxygen species(ROS),while the disulfide-bridged bonds regulated oxidative stress levels through reacting with glu-tathione(GSH);simultaneously,modification of TF improved recognition and endocytosis of the nanovesi-cle for tumor cells.Based on in-vitro results,a controlled-release behavior of DOX upon a dual-responsiveness of GSH and near-infrared ray(NIR)irradiation was presented,along with high-efficiency generation of ROS.After an intravenous injection,the nanovesicle was targeted at tumor sites,realizing TF-navigated photoacoustic imaging guidance and synergistic chemotherapy-photodynamic therapy under NIR/GSH stimulations.Overall,newly-synthesized DOX@Ir-TF nanovesicle provided a potential in subcuta-neous hepatocellular carcinoma therapy due to integrations of targeting delivery,dual-stimuli responsive release,synergistic therapy strategy,and real-time monitoring.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Jinyu Guo , Yandai Lin , Shaohua He et al. Utilizing dual-responsive iridium(Ⅲ)complex for hepatocellular carcinoma:Integrating photoacoustic imaging with chemotherapy and photodynamic therapy [J]. | 中国化学快报（英文版） , 2024 , 35 (9) : 296-302 . |
| MLA | Jinyu Guo et al. "Utilizing dual-responsive iridium(Ⅲ)complex for hepatocellular carcinoma:Integrating photoacoustic imaging with chemotherapy and photodynamic therapy" . | 中国化学快报（英文版） 35 . 9 (2024) : 296-302 . |
| APA | Jinyu Guo , Yandai Lin , Shaohua He , Yueqing Chen , Fenglu Li , Renjie Ruan et al. Utilizing dual-responsive iridium(Ⅲ)complex for hepatocellular carcinoma:Integrating photoacoustic imaging with chemotherapy and photodynamic therapy . | 中国化学快报（英文版） , 2024 , 35 (9) , 296-302 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Export
| Results： |
Selected to |
| Format： |
