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Abstract:
The combination of biomimetic scaffolds and nano drug delivery has been proposed to be an effective solution to the inherent limitations of the former in regulating cell behavior and bone tissue regeneration. Herein, a series of three-dimensional (3D) aspirin-loaded polylactic acid/graphene oxide (PLA/GO) porous biomimetic nanofibrous composite scaffolds (PBNCSs) was successfully prepared by phase separation. Results showed that the PLA/GO scaffolds have a biomimetic nanofibrous porous structure and a thin GO film covering the PLA nanofibers, which endows the latter with significantly improved hydrophilicity. Close interactions were noted in the GO-PLA interface. GO reduced the mechanical properties of the composite scaffolds but increased their thermal stability. The water absorption rate increased from 12.5% to 206.81% as the GO content increased from 0 to 5%. Addition of GO improved the deposition rate and amount of hydroxyapatite on the scaffolds. Overall, the PLA/GO PBNCSs demonstrated good cytocompatibility and sustained-release performance.
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POLYMER
ISSN: 0032-3861
Year: 2020
Volume: 211
4 . 4 3
JCR@2020
4 . 1 0 0
JCR@2023
ESI Discipline: CHEMISTRY;
ESI HC Threshold:160
JCR Journal Grade:1
CAS Journal Grade:2
Cited Count:
WoS CC Cited Count: 29
SCOPUS Cited Count: 40
ESI Highly Cited Papers on the List: 0 Unfold All
WanFang Cited Count:
Chinese Cited Count:
30 Days PV: 0
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