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author:

Liu, Shuqiong (Liu, Shuqiong.) [1] | Zheng, Yuying (Zheng, Yuying.) [2] (Scholars:郑玉婴) | Wu, Zhenzeng (Wu, Zhenzeng.) [3] | Hu, Jiapeng (Hu, Jiapeng.) [4] | Liu, Ruilai (Liu, Ruilai.) [5]

Indexed by:

EI Scopus SCIE

Abstract:

The combination of biomimetic scaffolds and nano drug delivery has been proposed to be an effective solution to the inherent limitations of the former in regulating cell behavior and bone tissue regeneration. Herein, a series of three-dimensional (3D) aspirin-loaded polylactic acid/graphene oxide (PLA/GO) porous biomimetic nanofibrous composite scaffolds (PBNCSs) was successfully prepared by phase separation. Results showed that the PLA/GO scaffolds have a biomimetic nanofibrous porous structure and a thin GO film covering the PLA nanofibers, which endows the latter with significantly improved hydrophilicity. Close interactions were noted in the GO-PLA interface. GO reduced the mechanical properties of the composite scaffolds but increased their thermal stability. The water absorption rate increased from 12.5% to 206.81% as the GO content increased from 0 to 5%. Addition of GO improved the deposition rate and amount of hydroxyapatite on the scaffolds. Overall, the PLA/GO PBNCSs demonstrated good cytocompatibility and sustained-release performance.

Keyword:

3D nanofibrous Polylactic acid/graphene oxide Sustained-release

Community:

  • [ 1 ] [Liu, Shuqiong]Fuzhou Univ, Coll Mat Sci & Engn, Fuzhou 350108, Peoples R China
  • [ 2 ] [Zheng, Yuying]Fuzhou Univ, Coll Mat Sci & Engn, Fuzhou 350108, Peoples R China
  • [ 3 ] [Liu, Shuqiong]Wuyi Univ, Coll Ecol & Resource Engn, Wuyishan 354300, Peoples R China
  • [ 4 ] [Wu, Zhenzeng]Wuyi Univ, Coll Ecol & Resource Engn, Wuyishan 354300, Peoples R China
  • [ 5 ] [Hu, Jiapeng]Wuyi Univ, Coll Ecol & Resource Engn, Wuyishan 354300, Peoples R China
  • [ 6 ] [Liu, Ruilai]Wuyi Univ, Coll Ecol & Resource Engn, Wuyishan 354300, Peoples R China

Reprint 's Address:

  • 郑玉婴

    [Zheng, Yuying]Fuzhou Univ, Coll Mat Sci & Engn, Fuzhou 350108, Peoples R China

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Source :

POLYMER

ISSN: 0032-3861

Year: 2020

Volume: 211

4 . 4 3

JCR@2020

4 . 1 0 0

JCR@2023

ESI Discipline: CHEMISTRY;

ESI HC Threshold:160

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count: 29

SCOPUS Cited Count: 40

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 0

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