The　combination　of　biomimetic　scaffolds　and　nano　drug　delivery　has　been　proposed　to　be　an　effective　solution　to　the　inherent　limitations　of　the　former　in　regulating　cell　behavior　and　bone　tissue　regeneration.　Herein,　a　series　of　three-dimensional　(3D)　aspirin-loaded　polylactic　acid/graphene　oxide　(PLA/GO)　porous　biomimetic　nanofibrous　composite　scaffolds　(PBNCSs)　was　successfully　prepared　by　phase　separation.　Results　showed　that　the　PLA/GO　scaffolds　have　a　biomimetic　nanofibrous　porous　structure　and　a　thin　GO　film　covering　the　PLA　nanofibers,　which　endows　the　latter　with　significantly　improved　hydrophilicity.　Close　interactions　were　noted　in　the　GO–PLA　interface.　GO　reduced　the　mechanical　properties　of　the　composite　scaffolds　but　increased　their　thermal　stability.　The　water　absorption　rate　increased　from　12.5%　to　206.81%　as　the　GO　content　increased　from　0　to　5%.　Addition　of　GO　improved　the　deposition　rate　and　amount　of　hydroxyapatite　on　the　scaffolds.　Overall,　the　PLA/GO　PBNCSs　demonstrated　good　cytocompatibility　and　sustained-release　performance.　©　2020