The　bioconversion　characteristics　of　L-phenylalanine　(Phe)　to　2-phenylethanol　(Pea)　by　the　yeast　Saccharomyces　cerevisiae　in　normal　fed-batch　culture　and　ISPR-fed-batch　culture　were　studied　respectively.　In　the　normal　fed-batch　culture,　the　glucose　concentration　was　controlled　in　0.1　~0.3　g/L　and　then　the　byproduct　ethanol　concentration　was　lower　than　1%,　but　the　final　Pea　concentration　was　lower　than　3.85　g/L.　Higher　Pea　concentration　could　not　be　attained　due　to　the　product　inhibition.　Macroporous　resin　FD0816　was　chosen　as　a　product　in　situ　extraction　material,　the　final　Pea　concentration　reached　12.80　g/L,　and　Pea　average　production　rate　0.38　g/(L·h),　which　were　improved　by　232%　and　35.7%　respectively　as　compared　with　that　without　resin　addition.　The　resin　used　in　fermentation　was　dynamically　eluted　by　ethanol　solution,　the　stripping　rate　was　more　than　95%　and　Pea　concentration　in　eluent　achieved　60　g/L.