Base damages induced in DNA by 10 eV electrons: Contribution to the radiosensitization mechanism of platinum chemotherapeutic drugs - Details

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Liu, W. (Liu, W..) ^[1] | Gao, Y. (Gao, Y..) ^[2] | Lemelin, V. (Lemelin, V..) ^[3] | Zheng, Y. (Zheng, Y..) ^[4] | Sanche, L. (Sanche, L..) ^[5]

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Abstract：

Binding　of　Pt-drugs　to　DNA　significantly　enhaces　base　damages,　crosslinks,　double　strand　breaks　(DSBs)　and　non-DSB　cluster　lesions　induced　by　10　eV　electrons.　This　enhancement　of　potentially　lethal　lesions　is　due　to　a　modification　of　electron-DNA　interactions,　which　contributes　to　the　synergy　between　chemo-　and　radiotherapy,　when　these　modalities　are　administered　in　concomitance　during　cancer　treatments.　©　2019　Published　under　licence　by　IOP　Publishing　Ltd.

Keyword：

DNA Platinum

Community：

[ 1 ] [Liu, W.]Research Institute of Photocatalysis, State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, Fuzhou; 350116, China
[ 2 ] [Gao, Y.]Research Institute of Photocatalysis, State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, Fuzhou; 350116, China
[ 3 ] [Lemelin, V.]Group in the Radiation Sciences, Faculty of Medicine, Université de Sherbrooke, Sherbrooke; QC; J1H 5N4, Canada
[ 4 ] [Zheng, Y.]Research Institute of Photocatalysis, State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, Fuzhou; 350116, China
[ 5 ] [Sanche, L.]Group in the Radiation Sciences, Faculty of Medicine, Université de Sherbrooke, Sherbrooke; QC; J1H 5N4, Canada

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ISSN： 1742-6588

Year： 2020

Issue： 20

Volume： 1412

Language： English

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ESI Highly Cited Papers on the List： 0 Unfold All

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