The　uncertainty　and　accuracy　can　not　be　considered　in　the　finite　element　(FE)　updating,　and　the　FE　model　validation　a　development　of　the　FE　model　updating.　In　the　two-paper　series,　the　methods　of　FE　model　validation　were　established.　As　one　of　the　key　problems　in　the　FE　model　validation,　the　model　updating　method　based　on　the　response　surface　model　was　developed.　Several　key　steps,　such　as　the　design　of　experiments,　parameter　screening,　selection　of　response　surface　model　and　model　accuracy　inspection,　were　included.　Using　the　online　bridge　health　monitoring　system　of　the　Xiabaishi　bridge,　the　finite　element　model　updating　based　on　the　response　surface　model　was　conducted　successfully.　It　can　be　concluded　that　the　results　from　the　updated　model　are　in　good　agreement　with　the　measurements,　with　the　maximum　error　being　no　larger　than　6%.　The　updated　finite　element　model　can　be　employed　for　model　validation,　bridge　health　monitoring　and　safety　evaluation.