The　dynamic　behavior　of　a　multi-span　continuous　curved　bridge　under　heavy　trucks　passing　was　investigated,　the　bridge　was　discretized　with　a　triple-beam　model　and　the　trucks　were　simulated　with　a　12-DOF　model.　The　inverse　fast　Fourier　transformation　was　applied　to　simulate　road　irregularity　and　its　velocity　term　of　grade　B　according　to　the　power　spectral　density　of　road　roughness.　The　impact　effects　at　various　positions　of　the　curved　bridge　under　multi-vehicle　action　with　different　velocities　were　investigated　considering　the　bridge　structural　damping　using　the　separated　iteration　method　based　on　ANSYS.　The　analysis　results　showed　that　the　number　of　lateral　loading　lanes　has　a　great　effect　on　the　fulcrum　and　the　mid-span　torques,　the　fulcrum　bending　moment　and　the　bending　moment　maximum　dynamic　amplification　factor　of　the　top　pier　cross-section,　while　it　has　little　effect　on　the　maximum　deflection　dynamic　amplification　factor　of　the　girder　and　the　maximum　axial　force　dynamic　amplication　factor　of　the　pier;　the　number　of　longitudinal　loading　vehicles　has　significant　influence　on　the　bridge　impact　effects;　the　impact　factors　increase　with　increase　in　space　headway　but　the　corresponding　maximum　responses　decrease.　The　presented　results　provided　a　reference　for　design　of　continuous　curved　box　girder　bridges.