An　ANSYS-based　spatial　approach　of　analysis　is　proposed　for　the　bridge-vehicle　interaction　to　investigate　the　dynamic　responses　of　a　curved　concrete　box　girder　bridge　and　vehicles.　The　governing　equations　of　a　vehicle　model　with　twelve-degrees-of-freedom　(12DOF)　are　derived　from　the　energy　method　using　the　Lagrange　equation　of　motion.　Both　the　bridge　and　the　vehicle　system　are　discretized　adopting　element　type　BEAM44,　MASS21　and　COMBIN14　in　the　ANSYS　program.　The　interaction　forces　between　the　vehicle　and　bridge　are　deduced　considering　the　road　surface　roughness　and　its　velocity　term　based　on　the　compatibility　conditions　of　the　contact　points,　and　detailed　formula　are　presented.　The　separate　iterative　algorithm　is　developed　to　solve　the　vehicle-bridge　interaction　problem.　A　three-axle　cargo　truck　and　a　dual-cell　box　girder　curved　overpass　bridge　are　chosen　for　both　numerical　and　field　test　analysis.　The　dynamic　properties　and　the　dynamic　responses　of　the　bridge　are　both　obtained　from　the　numerical　and　experiment　way,　and　the　results　agree　well　with　each　other　by　comparison.　It＇s　indicated　that　the　procedures　presented　in　this　paper　can　be　taken　for　the　further　vibration　analysis　study　of　curved　concrete　box　girder　bridges.　©　(2014)　Trans　Tech　Publications.