As　a　newly　developed　technique,　photoelectrochemical　(PEC)　immunoassays　have　attracted　great　attention　in　recent　years　because　of　their　low　cost　and　desirable　sensitivity.　Because　the　detection　signal　originates　from　the　photoelectric　conversion　of　photoelectric　materials,　the　appearance　and　application　of　quantum　dots　(QDs),　which　possess　unique　photophysical　properties　and　regulated　optoelectronic　characteristics,　has　taken　the　development　of　PEC　immunoassays　to　new　heights.　This　review　concisely　introduces　the　general　mechanism　of　QDs-based　photoelectric　conversion　for　immunoassays　and　summarizes　the　current　advances　in　QD　applications　in　immunoassays.　Given　that　signal　strategies　and　photoactive　materials　are　the　key　elements　in　PEC　biosensor　systems,　we　comprehensively　highlight　the　state-of-the-art　signaling　strategies　and　various　applications　of　QDs　in　PEC　immunoassays　to　introduce　advances　in　QDs-based　PEC　immunoassays.　Finally,　challenges　and　future　developmental　trends　are　briefly　discussed.　©　2017　Wiley-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim