Background:　The　construction　of　a　multifunctional　drug　delivery　system　with　a　variety　of　advantageous　features,　including　targeted　delivery,　controlled　release　and　combined　therapy,　is　highly　attractive　but　remains　a　challenge.　Results:　In　this　study,　we　developed　a　MoS2-based　hyaluronic　acid　(HA)-functionalized　nanoplatform　capable　of　achieving　targeted　delivery　of　camptothecin　(CPT)　and　dual-stimuli-responsive　drug　release.　HA　was　connected　to　MoS2　via　a　disulfide　linkage,　forming　a　sheddable　HA　shell　on　the　surface　of　MoS2.　This　unique　design　not　only　effectively　prevented　the　encapsulated　CPT　from　randomly　leaking　during　blood　circulation　but　also　significantly　accelerated　the　drug　release　in　response　to　tumor-associated　glutathione　(GSH).　Moreover,　the　MoS2-based　generated　heat　upon　near-infrared　(NIR)　irradiation　could　further　increase　the　drug　release　rate　as　well　as　induce　photothermal　ablation　of　cancer　cells.　The　results　of　in　vitro　and　in　vivo　experiments　revealed　that　MoS2-SS-HA-CPT　effectively　suppressed　cell　proliferation　and　inhibited　tumor　growth　in　lung　cancer　cell-bearing　mice　under　NIR　irradiation　via　synergetic　chemo-photothermal　therapy.　Conclusions:　The　as-prepared　MoS2-SS-HA-CPT　with　high　targeting　ability,　dual-stimuli-responsive　drug　release,　and　synergistic　chemo-photothermal　therapy　may　provide　a　new　strategy　for　cancer　therapy.　©　2019　The　Author(s).