Monitoring a tumor-targeting BODIPY-based theranostic nanomaterial with photoacoustic imaging - Details

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Abstract：

Photoacoustic　imaging　has　begun　to　be　widely　used　to　observe　drug　delivery　and　accumulation　in　the　body.　Theranostic,　which　includes　both　diagnosis　and　therapy,　is　an　attractive　approach　for　treating　cancer.　In　this　study,　we　synthesized　nanomaterials　and　verified　the　theranostic　effect　through　fluorescence　and　photoacoustic　imaging.　Selectively　transporting　a　drug　to　the　tumor　site　is　essential　to　increase　the　therapeutic　effect　while　reducing　side　effects.　BODIPY　has　the　advantages　of　being　able　to　change　its　structure　more　easily,　good　photostability,　good　biocompatibility　and　high　absorption　coefficient　than　cyanine　or　porphyrin　dyes,　however　they　are　limited　to　in　vivo　experiment　due　to　their　poor　water　solubility.　We　overcome　the　limitations　of　BODIPY-based　materials　by　encapsulating　in　micellar　nanoparticles　with　Hexa　BODIPY　cyclophosphazene　(HBCP)　and　DSPE-PEG2000　polymer.　HBCP　NPs　also　have　a　property　of　selectively　accumulating　in　tumors　with　enhanced　permeability　and　retention　effect　due　to　their　bulky　nano-size　molecular　structure.　We　checked　the　tumor　targeting　and　retention　time　of　HBCP　NPs　by　monitoring　them　with　fluorescence　imaging.　In　addition,　the　high　heat　conversion　efficiency　of　HBCP　NPs　enables　photoacoustic　imaging　and　Photothermal　therapy.　We　also　conducted　whole　body　scanning　of　tail-vein　injected　tumor-bearing　mice　with　acoustic　resolution　photoacoustic　microscopy　system　to　provide　tumor　accumulation　information　of　HBCP　NP　with　vascular　structure.　The　result　suggests　that　HBCP　NP　has　a　potential　to　be　used　as　a　material　for　image　guided　phototherapy.　©　2023　SPIE.

Keyword：

Biocompatibility Controlled drug delivery Conversion efficiency Diagnosis Fluorescence imaging Mammals Nanostructured materials Photoacoustic effect Photoacoustic microscopy Targeted drug delivery Tumors Water absorption

Community：

[ 1 ] [Park, Sinyoung]Department of Electrical Engineering, Convergence IT Engineering, Mechanical Engineering, School of Interdisciplinary Bioscience and Bioengineering, Graduate School of Artificial Intelligence, Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk; 37673, Korea, Republic of
[ 2 ] [Park, Eun-Yeong]Department of Radiology, School of Medicine, Stanford University, Stanford; CA; 94305, United States
[ 3 ] [Kwon, Nahyun]Department of Chemistry and Nano Science, Ewha Womans University, Seoul; 03760, Korea, Republic of
[ 4 ] [Kim, Kwang H.]Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul; 03722, Korea, Republic of
[ 5 ] [Cho, Yejin]Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul; 03722, Korea, Republic of
[ 6 ] [Lim, Junha]Department of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, Pohang University of Science and Technology (POSTECH), Pohang; 37673, Korea, Republic of
[ 7 ] [Çetindere, Seda]Department of Chemistry, Gebze Technical University, Kocaeli, Gebze; 41400, Turkey
[ 8 ] [Tümay, Süreyya Ouz]Department of Chemistry, Gebze Technical University, Kocaeli, Gebze; 41400, Turkey
[ 9 ] [Kim, Won Jong]Department of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, Pohang University of Science and Technology (POSTECH), Pohang; 37673, Korea, Republic of
[ 10 ] [Li, Xingshu]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou; 350108, China
[ 11 ] [Nam, Ki Taek]Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul; 03722, Korea, Republic of
[ 12 ] [Yeilot, Serkan]Department of Chemistry, Gebze Technical University, Kocaeli, Gebze; 41400, Turkey
[ 13 ] [Yoon, Juyoung]Department of Chemistry and Nano Science, Ewha Womans University, Seoul; 03760, Korea, Republic of
[ 14 ] [Kim, Chulhong]Department of Electrical Engineering, Convergence IT Engineering, Mechanical Engineering, School of Interdisciplinary Bioscience and Bioengineering, Graduate School of Artificial Intelligence, Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk; 37673, Korea, Republic of

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