A　simple,　reliable　and　reproducible　method　for　separation　and　determination　of　levodopa　and　carbidopa　based　on　capillary　electrophoresis　with　amperometric　detection　is　described　in　this　paper.　A　potential　of　900　mV　(versus　Ag/AgCl　3　mol/l　KCl)　was　applied　to　the　carbon　disk　electrode,　which　was　used　as　working　electrode　in　this　system.　Under　the　optimum　conditions,　two　analytes　were　separated　completely　within　12　min,　with　linear　ranges　of　1.2-100.0　and　1.2-150.0　mug/ml,　and　detection　limits　of　0.6　and　0.3　mug/ml　for　levodopa　and　carbidopa,　respectively.　The　mean　recoveries　of　levodopa　and　carbidopa　were　97.4　and　102.3%.　The　method　was　applied　successfully　to　the　determination　in　the　real　pharmaceutical　samples.　(C)　2001　Elsevier　Science　B.V.　All　rights　reserved.