In　this　paper,　the　electrogenerated　chemiluminescence　(ECL)　behavior　of　6-(4-methoxyphenyl)-2-methylimidazo[1,2-a]pyrazin-3(7H)-one　(MCLA)　at　an　indium-tin-oxide　(ITO)　electrode　in　phosphate　buffer　solution　has　been　investigated　when　linear　sweep　voltammetry　was　applied.　The　optimum　chemical　conditions　and　electrochemical　parameters　for　this　ECL　system　have　been　investigated　in　detail.　Under　the　optimum　conditions,　it　was　found　that　the　ECL　intensity　was　linear　with　the　concentration　of　MCLA　in　the　range　of　6.0　x　10(-7)　to　1.0　x　10(-5)　mol/L,　and　its　detection　limit　for　MCLA　was　2.0　x　10(-7)　mol/L.　The　possible　mechanism　for　ECL　of　MCLA　at　the　ITO　electrode　was　also　discussion.　Furthermore,　it　was　found　that　some　sophora　flavescens,　such　as　matrine　and　oxymatrine,　might　enhance　the　ECL　intensity　of　MCLA.　Therefore,　it　is　possible　to　develop　a　new　ECL　method　for　determination　of　matrine　and　oxymatrine.　(c)　2006　Elsevier　Ltd.　All　rights　reserved.