Two　novel　chlorinated　sorbicillinoids　named　chloctanspirones　A　(1)　and　B　(2),　possessing　an　un-precedented　bicyclo[2.2.2]octane-2-spiro　cyclohexane　skeleton,　together　with　their　quasi-precursors　terrestrols　K　(3)　and　L　(4),　two　additional　new　chlorinated　compounds,　were　isolated　from　a　marine　sediment　derived　fungus　Penicillium　terrestre.　Their　structures　including　absolute　stereochemistries　were　elucidated　by　analysis　of　NMR,　MS　data,　and　TDDFT　CD　calculations.　The　cytotoxic　effects　of　1-4　were　preliminarily　evaluated　in　HL-60　and　A-549　cells.　Compound　1　was　active　against　both　HL-60　and　A-549　cells　with　IC(50)s　9.2　and　39.7　mu　M,　respectively,　while　2　showed　weaker　activity　only　against　HL-60　cells　(IC50　37.8　mu　M).　(C)　2011　Elsevier　Ltd.　All　rights　reserved.