Chloctanspirones A and B, novel chlorinated polyketides with an unprecedented skeleton, from marine sediment derived fungus Penicillium terrestre - Details

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Abstract：

Two　novel　chlorinated　sorbicillinoids　named　chloctanspirones　A　(1)　and　B　(2),　possessing　an　unprecedented　bicyclo[2.2.2]octane-2-spiro　cyclohexane　skeleton,　together　with　their　quasi-precursors　terrestrols　K　(3)　and　L　(4),　two　additional　new　chlorinated　compounds,　were　isolated　from　a　marine　sediment　derived　fungus　Penicillium　terrestre.　Their　structures　including　absolute　stereochemistries　were　elucidated　by　analysis　of　NMR,　MS　data,　and　TDDFT　CD　calculations.　The　cytotoxic　effects　of　1-4　were　preliminarily　evaluated　in　HL-60　and　A-549　cells.　Compound　1　was　active　against　both　HL-60　and　A-549　cells　with　IC50s　9.2　and　39.7　μM,　respectively,　while　2　showed　weaker　activity　only　against　HL-60　cells　(IC50　37.8　μM).　©　2011　Elsevier　Ltd.　All　rights　reserved.

Keyword：

Marine derived fungus; Penicillium terrestre; Sorbicillinoids

Community：

[ 1 ] [Li, D.]Key Laboratory of Marine Drugs, Chinese Ministry of Education, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, China
[ 2 ] [Li, D.]School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, China
[ 3 ] [Chen, L.]Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, 2 Xueyuan Road, Fuzhou, Fujian 350002, China
[ 4 ] [Zhu, T.]Key Laboratory of Marine Drugs, Chinese Ministry of Education, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, China
[ 5 ] [Zhu, T.]School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, China
[ 6 ] [Kurtán, T.]Department of Organic Chemistry, University of Debrecen, POB 20, 4010 Debrecen, Hungary
[ 7 ] [Mándi, A.]Department of Organic Chemistry, University of Debrecen, POB 20, 4010 Debrecen, Hungary
[ 8 ] [Zhao, Z.]Key Laboratory of Marine Drugs, Chinese Ministry of Education, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, China
[ 9 ] [Zhao, Z.]School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, China
[ 10 ] [Li, J.]Key Laboratory of Marine Drugs, Chinese Ministry of Education, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, China
[ 11 ] [Li, J.]School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, China
[ 12 ] [Gu, Q.]Key Laboratory of Marine Drugs, Chinese Ministry of Education, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, China
[ 13 ] [Gu, Q.]School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, China

Reprint 's Address：

[Kurtán, T.]Department of Organic Chemistry, University of Debrecen, POB 20, 4010 Debrecen, Hungary

Email：

kurtant@tigris.klte.hu

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Source ：

Tetrahedron

ISSN： 0040-4020

Year： 2011

Issue： 41

Volume： 67

Page： 7913-7918

3 . 0 2 5

JCR@2011

2 . 1 0 0

JCR@2023

JCR Journal Grade：2

CAS Journal Grade：3

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SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

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Chinese Cited Count：

30 Days PV： 2

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