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学者姓名：陈立
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| GB/T 7714 | Chen, Li , Li, Xinxin , Cheng, Miaomiao et al. 撤稿声明: Iso-pencillixanthone A from a marine-derived fungus reverses multidrug resistance in cervical cancer cells through down-regulating P-gp and re-activating apoptosis [J]. | RSC ADVANCES , 2025 , 15 (1) : 712-712 . |
| MLA | Chen, Li et al. "撤稿声明: Iso-pencillixanthone A from a marine-derived fungus reverses multidrug resistance in cervical cancer cells through down-regulating P-gp and re-activating apoptosis" . | RSC ADVANCES 15 . 1 (2025) : 712-712 . |
| APA | Chen, Li , Li, Xinxin , Cheng, Miaomiao , Wang, Siyuan , Zheng, Qiuhong , Liu, Qinying . 撤稿声明: Iso-pencillixanthone A from a marine-derived fungus reverses multidrug resistance in cervical cancer cells through down-regulating P-gp and re-activating apoptosis . | RSC ADVANCES , 2025 , 15 (1) , 712-712 . |
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The escalating threats posed by industrial wastewater discharge and offshore crude oil spills necessitate the development of cost-effective, environmentally friendly adsorbents. In this study, stearic acid-modified (SA) magnetic porous hydroxyapatite (HAP) microspheres were prepared by hydrothermal synthesis. Abalone shell particles were employed as the calcium source, and Fe3O4 nanoparticles (nFe3O4) or industrial iron tetraoxide particles (Fe3O4) were selected as the magnetic source. The microsphere (SA/nFe3O4-HAP) demonstrated enhanced superhydrophobicity, lipophilicity and increased specific surface area, with an oil absorption capacity of 6.518 g/g. Notably, compared to SA/Fe3O4-HAP, the magnetic particles on SA/nFe3O4-HAP exhibited more even dispersion. The excellent superparamagnetism and hydrophobicity of SA/nFe3O4-HAP facilitated its dispersion in crude oil, enabling efficient magnetic separation. After five cycles, the adsorption efficiency remained high 4.213 g/g, signifying its good recyclability. In conclusion, this environmentally friendly adsorbent demonstrates synergistic efficacy in addressing marine oil spills and discarded shell pollution, offering a potential balance between environmental and economic benefits.
Keyword ：
Abalone shell Abalone shell Crude oil Crude oil Environmental protection Environmental protection Hydroxyapatite microspheres Hydroxyapatite microspheres Magnetic adsorbent Magnetic adsorbent
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| GB/T 7714 | Ding, Wanying , Liu, Man , Xing, Yuanhao et al. Stearic acid-modified magnetic porous hydroxyapatite microspheres for efficient marine oil spill treatment [J]. | JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING , 2025 , 13 (2) . |
| MLA | Ding, Wanying et al. "Stearic acid-modified magnetic porous hydroxyapatite microspheres for efficient marine oil spill treatment" . | JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING 13 . 2 (2025) . |
| APA | Ding, Wanying , Liu, Man , Xing, Yuanhao , Tie, Dan , Chen, Zheng , Li, Jiazhen et al. Stearic acid-modified magnetic porous hydroxyapatite microspheres for efficient marine oil spill treatment . | JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING , 2025 , 13 (2) . |
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In anterior cruciate ligament (ACL) repair methods, the continuous enzymatic erosion of synovial fluid can impede healing and potentially lead to repair failure, as well as exacerbate articular cartilage wear, resulting in joint degeneration. Inspired by the blood clot during medial collateral ligament healing, we developed a composite scaffold comprising collagen (1 %, w/v) and polyvinyl alcohol (5 %, w/v) combined with platelet-rich plasma (PRP). The composite scaffold provides a protective barrier against synovial erosion for the ruptured ACL, while simultaneously facilitating tissue repair, thereby enhancing the efficacy of ACL repair techniques. The composite scaffold is primarily formed through hydrogen bonding between molecular chains and physical cross- linking of microcrystalline regions using a simple cyclic freeze-thaw method, resulting in improved mechanical properties and an extended degradation period. The maximum tensile fracture load of the composite scaffold reached 5.99 +/- 0.30 N. The incorporation of PRP facilitates cell migration, proliferation, and blood vessel growth by enabling slow release of various growth factors. In vivo results demonstrate that this composite scaffold promotes rabbit hindlimb rupture ACL healing by stimulating fibroblast proliferation, collagen deposition, microvascular formation, and proprioceptor generation. Furthermore, it effectively reduces meniscus and cartilage wear while mitigating bone arthritis and joint degenerative diseases. Overall, our proposed composite scaffold holds great promise as a candidate for ACL healing.
Keyword ：
Anterior cruciate ligament Anterior cruciate ligament Biodegradable scaffold Biodegradable scaffold Collagen Collagen Platelet-rich plasma Platelet-rich plasma Polyvinyl alcohol Polyvinyl alcohol
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| GB/T 7714 | Sun, Xiaohan , Zhang, Nanxin , Chen, Longhui et al. Collagen/polyvinyl alcohol scaffolds combined with platelet-rich plasma to enhance anterior cruciate ligament repair [J]. | BIOMATERIALS ADVANCES , 2025 , 169 . |
| MLA | Sun, Xiaohan et al. "Collagen/polyvinyl alcohol scaffolds combined with platelet-rich plasma to enhance anterior cruciate ligament repair" . | BIOMATERIALS ADVANCES 169 (2025) . |
| APA | Sun, Xiaohan , Zhang, Nanxin , Chen, Longhui , Lai, Yuchao , Yang, Shasha , Li, Qiang et al. Collagen/polyvinyl alcohol scaffolds combined with platelet-rich plasma to enhance anterior cruciate ligament repair . | BIOMATERIALS ADVANCES , 2025 , 169 . |
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Cytokinin (CK) is a type of hormone that exists widely in plants and plays a significant role in promoting cell proliferation and division. Developing a rapid and sensitive method for the detection of trace CKs remains challenging. Microporous organic networks (MONs) are novel materials widely used in sample preparation owing to their excellent extraction performance. Therefore, a dispersive solid phase extraction method based on carboxylated microporous organic networks (MON-2COOH), combined with ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the detection of four CKs was developed. Upon introducing a carboxyl group into pure MON, the MON-2COOH material had excellent stability, high porosity, and a good dispersion effect, and provided more interaction sites to achieve good adsorption of target compounds. Under the best conditions, the established dSPE-UPLC-MS/MS method had the advantages of low adsorbent dosage (2 mg), low detection limit (1.0-10.0 pg mL-1) and good reproducibility (RSD <= 6.54%, n = 5). Synergistic extraction mechanisms involving pi-pi, hydrogen bonding and hydrophobic interactions were elucidated using both density functional theory calculations and experimental data. This work also confirmed the feasibility of functionalized MONs as satisfactory adsorbents for the enrichment of small organic compounds.
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| GB/T 7714 | Chen, Li , Yu, Tao , Huang, Le et al. Effective extraction of trace cytokinins in plants based on a carboxyl functionalized microporous organic network [J]. | ANALYTICAL METHODS , 2025 , 17 (16) : 3320-3330 . |
| MLA | Chen, Li et al. "Effective extraction of trace cytokinins in plants based on a carboxyl functionalized microporous organic network" . | ANALYTICAL METHODS 17 . 16 (2025) : 3320-3330 . |
| APA | Chen, Li , Yu, Tao , Huang, Le , Lu, Qiaomei , Zhang, Wenmin , Zhang, Lan . Effective extraction of trace cytokinins in plants based on a carboxyl functionalized microporous organic network . | ANALYTICAL METHODS , 2025 , 17 (16) , 3320-3330 . |
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Inspired by the formation of natural abalone shells (AS) similar to calcium salt deposition in human orthodontics, AS is used as an emulsifier in the scaffold to solve the problem of coexistence of natural and synthetic polymers and promote new bone formation. In this study, AS-stabilized and reinforced carboxymethyl chitosan/collagen/PLGA porous bionic composite scaffolds (AS/CMCS/Col/PLGA) were fabricated through the emulsion polymerization and bionic hybrid technology. As the addition of AS increased from 0.75 to 3.0 wt%, homogeneous distribution of flower-like particles could be observed on the inner surface of the scaffold, and its mechanical properties were improved. Particularly, 3.0 wt% AS-doped scaffolds (S3 and C + S3) exhibited excellent inorganic mineral deposition and osteoblast proliferation and differentiation abilities in vitro. In a SD rat calvarial defect model, they effectively promoted new bone formation in the defect and accelerated expression of osteogenic-angiogenic related proteins (COLI, OCN, VEGF). By virtue of its combined merits including good mechanical properties, inducing mineralization crystallization and facilitating osteogenesis, the 3.0 wt% AS-doped scaffold promises to be employed as a novel bone repair material for bone tissue regeneration. © 2024 Elsevier B.V.
Keyword ：
Abalone shell Abalone shell Bionic hybrid scaffold Bionic hybrid scaffold Carboxymethyl chitosan Carboxymethyl chitosan
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| GB/T 7714 | Pan, P. , Hu, Y. , Wang, C. et al. Abalone shells bioenhanced carboxymethyl chitosan/collagen/PLGA bionic hybrid scaffolds achieving biomineralization and osteogenesis for bone regeneration [J]. | International Journal of Biological Macromolecules , 2024 , 279 . |
| MLA | Pan, P. et al. "Abalone shells bioenhanced carboxymethyl chitosan/collagen/PLGA bionic hybrid scaffolds achieving biomineralization and osteogenesis for bone regeneration" . | International Journal of Biological Macromolecules 279 (2024) . |
| APA | Pan, P. , Hu, Y. , Wang, C. , Liu, Q. , Hu, L. , Yu, H. et al. Abalone shells bioenhanced carboxymethyl chitosan/collagen/PLGA bionic hybrid scaffolds achieving biomineralization and osteogenesis for bone regeneration . | International Journal of Biological Macromolecules , 2024 , 279 . |
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Antioxidants are crucial for balancing free radicals, activating the body's defense system, and reducing oxidative stress. Food-derived antioxidant peptides have broad applications in food and biomedical industries, yet understanding their complex composition and molecular mechanisms remains incomplete. Our previous studies have indicated that bass fish (Lateolabrax japonicus) hydrolysates (LPH) possess antioxidant properties. This study aimed to identify and analyze novel antioxidant peptides from LPH using biochemical and computer-based studies. Five novel peptides were discovered, including AGFAGDDAPR, DDWENWAK, DWENWAK, EWDNFAK, and WGEDGYIR, with DDWENWAK showing remarkable antioxidant effects. DDWENWAK protected Caco-2 cells against H2O2-induced oxidative damage and improved mitochondrial energy metabolism via Nrf2 and AMPK pathways. Molecular docking affirmed the relationship between antioxidant properties and peptide structure, highlighting key hydrogen bonds and electrostatic interactions mediating peptide-receptor binding. These findings provide better insight into the antioxidant peptides' action mechanisms, aiding in the development of novel peptides for antioxidant-functional foods or pharmaceuticals.
Keyword ：
Antioxidant Antioxidant Caco-2 cells Caco-2 cells Characterization Characterization Energy homeostasis Energy homeostasis Molecular docking Molecular docking
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| GB/T 7714 | Li, Chen , Li, Lichan , Farag, Mohamed A. et al. Identification of novel antioxidant peptides from Lateolabrax japonicus and the underlying molecular mechanisms against oxidative stress injury in Caco-2 cells [J]. | FOOD BIOSCIENCE , 2024 , 62 . |
| MLA | Li, Chen et al. "Identification of novel antioxidant peptides from Lateolabrax japonicus and the underlying molecular mechanisms against oxidative stress injury in Caco-2 cells" . | FOOD BIOSCIENCE 62 (2024) . |
| APA | Li, Chen , Li, Lichan , Farag, Mohamed A. , Cai, Xixi , Wang, Shaoyun . Identification of novel antioxidant peptides from Lateolabrax japonicus and the underlying molecular mechanisms against oxidative stress injury in Caco-2 cells . | FOOD BIOSCIENCE , 2024 , 62 . |
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Sleep duration is one of the eight factors of health in life. High incidence of insomnia and other sleep disorders cause insufficient sleep. Chronic mild sleep deprivation leads to endothelial oxidative stress and impaired antioxidant response, which increases the risk of cardiovascular and cancer diseases over time. The lotus is a valuable agricultural commodity highly prized for its diverse edible and medicinal parts. lotus leaves as a part of the lotus, which contain the abundant bioactive substance Nuciferine (Nuc). Herein we found that Nuciferine significantly decreased spontaneous activity and sleep latency in mice, while markedly increasing sleep duration. Additionally, it has a sleep-enhancing effect by raising levels of gamma-aminobutyric acid (GABA) and lowering Glutamate (Glu), Dopamine (DA), and Norepinephrine (NE) in mouse plasma. This sleep-enhancing effect is impeded by Picrotoxin (Pic) and intensified by 5-hydroxytryptophan (5-HTP). The results indicate that Nuciferine may induce its sleep-enhancing effect through the GABAergic and monoaminergic nervous systems. Furthermore, this study constructed an insomnia model and revealed that Nuciferine could regulate inflammatory factors (including IL-1 beta and TNF-alpha) in plasma and brain tissue, resulting in successful treatment of insomnia in vivo. The c-fos immunofluorescence, Nissl staining and H&E staining illustrated a reversal of low neuronal activity in insomniac mice, demonstrating a protective effect on brain tissue structure. These findings suggest that Nuciferine, which is present in lotus leaves, may improve sleep quality by utilizing multiple pathways, decreasing low neuronal activity associated with insomnia, and reversing abnormalities in brain tissue.
Keyword ：
Lotus leaves Lotus leaves Neuroprotective Neuroprotective Neurotransmitter Neurotransmitter Nuciferine Nuciferine Sleep-enhancing effect Sleep-enhancing effect
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| GB/T 7714 | Zhang, Haijie , Wu, Yinbo , Qiu, Mengjie et al. Lotus leaf Nuciferine improves sleep and reduces the low neuronal activity and brain tissue abnormalities associated with insomnia [J]. | FOOD BIOSCIENCE , 2024 , 62 . |
| MLA | Zhang, Haijie et al. "Lotus leaf Nuciferine improves sleep and reduces the low neuronal activity and brain tissue abnormalities associated with insomnia" . | FOOD BIOSCIENCE 62 (2024) . |
| APA | Zhang, Haijie , Wu, Yinbo , Qiu, Mengjie , Zheng, Yunquan , Chen, Li , Shi, Xianai et al. Lotus leaf Nuciferine improves sleep and reduces the low neuronal activity and brain tissue abnormalities associated with insomnia . | FOOD BIOSCIENCE , 2024 , 62 . |
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As an emerging isoxazoline insecticide, afoxolaner has a good effect in the prevention and treatment of canine parasite infections. During the crystallization process of afoxolaner, inconsistent crystal phases and thermal properties are observed in the same batch of samples. In this work, the solubility and crystallization process were studied, and the best method was found to be slow evaporation in ethanol. The results showed that the crystal phase was highly consistent. The average peak value of DSC was observed at 149.6 +/- 0.6 degrees C, with a relative mean deviation of only 0.4%. Furthermore, the isolation of needle-like single crystals allowed for the determination of the crystal structure, revealing the enantiomeric pairs of afoxolaner co-crystallized with water in a monoclinic crystal system belonging to the centrosymmetric space group P21/n. It is hoped that this study will provide important insights into the crystallographic data of afoxolaner for its practical applications.
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| GB/T 7714 | Fang, Zong-Bin , Xiao, Yue-Feng , Sun, Chong et al. Solubility, crystallization process optimization, and thermal properties of afoxolaner and the single-crystal structure of its hydrate [J]. | CRYSTENGCOMM , 2024 , 27 (6) : 795-800 . |
| MLA | Fang, Zong-Bin et al. "Solubility, crystallization process optimization, and thermal properties of afoxolaner and the single-crystal structure of its hydrate" . | CRYSTENGCOMM 27 . 6 (2024) : 795-800 . |
| APA | Fang, Zong-Bin , Xiao, Yue-Feng , Sun, Chong , Chen, Xinyao , Zhou, Lingyu , Chen, Li et al. Solubility, crystallization process optimization, and thermal properties of afoxolaner and the single-crystal structure of its hydrate . | CRYSTENGCOMM , 2024 , 27 (6) , 795-800 . |
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Inspired by the formation of natural abalone shells (AS) similar to calcium salt deposition in human orthodontics, AS is used as an emulsifier in the scaffold to solve the problem of coexistence of natural and synthetic polymers and promote new bone formation. In this study, AS-stabilized and reinforced carboxymethyl chitosan/collagen/ PLGA porous bionic composite scaffolds (AS/CMCS/Col/PLGA) were fabricated through the emulsion polymerization and bionic hybrid technology. As the addition of AS increased from 0.75 to 3.0 wt%, homogeneous distribution of flower-like particles could be observed on the inner surface of the scaffold, and its mechanical properties were improved. Particularly, 3.0 wt% AS-doped scaffolds (S3 and C + S3) exhibited excellent inorganic mineral deposition and osteoblast proliferation and differentiation abilities in vitro. In a SD rat calvarial defect model, they effectively promoted new bone formation in the defect and accelerated expression of osteogenic-angiogenic related proteins (COLI, OCN, VEGF). By virtue of its combined merits including good mechanical properties, inducing mineralization crystallization and facilitating osteogenesis, the 3.0 wt% ASdoped scaffold promises to be employed as a novel bone repair material for bone tissue regeneration.
Keyword ：
Abalone shell Abalone shell Bionic hybrid scaffold Bionic hybrid scaffold Carboxymethyl chitosan Carboxymethyl chitosan
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| GB/T 7714 | Pan, Panpan , Hu, Yimin , Wang, Chunxiao et al. Abalone shells bioenhanced carboxymethyl chitosan/collagen/PLGA bionic hybrid scaffolds achieving biomineralization and osteogenesis for bone regeneration [J]. | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 279 . |
| MLA | Pan, Panpan et al. "Abalone shells bioenhanced carboxymethyl chitosan/collagen/PLGA bionic hybrid scaffolds achieving biomineralization and osteogenesis for bone regeneration" . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 279 (2024) . |
| APA | Pan, Panpan , Hu, Yimin , Wang, Chunxiao , Liu, Qing , Hu, Le , Yu, Hui et al. Abalone shells bioenhanced carboxymethyl chitosan/collagen/PLGA bionic hybrid scaffolds achieving biomineralization and osteogenesis for bone regeneration . | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , 2024 , 279 . |
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An efficient and rapid protocol for the oxidative halogenation of tryptamines with 10 % aqueous NaClO has been developed. This reaction is featured by its operational simplicity, metal-free conditions, no purification, and high yield. Notably, the resulting key intermediates are suitable for further functionalization with various nucleophiles, including amines, N-aromatic heterocycles, indoles and phenols. The overall transformation exhibits broad functional-group tolerance and is applicable to the late-stage functionalization of complex biorelevant molecules. An efficient and rapid protocol for the oxidative halogenation of tryptamines with 10 % aqueous NaClO has been developed. This reaction is featured by its operational simplicity, metal-free conditions, no purification, and high yield. The overall transformation exhibits broad functional-group tolerance and is applicable to the late-stage functionalization of complex biorelevant molecules. image
Keyword ：
Autophagy Autophagy Drug discovery Drug discovery Green chemistry Green chemistry Late-stage functionalization Late-stage functionalization Tryptamines Tryptamines
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| GB/T 7714 | Xu, Jiayi , Zhang, Yahui , Cai, Qiling et al. Green Late-Stage Functionalization of Tryptamines [J]. | CHEMISTRY-A EUROPEAN JOURNAL , 2024 , 30 (46) . |
| MLA | Xu, Jiayi et al. "Green Late-Stage Functionalization of Tryptamines" . | CHEMISTRY-A EUROPEAN JOURNAL 30 . 46 (2024) . |
| APA | Xu, Jiayi , Zhang, Yahui , Cai, Qiling , Chen, Li , Sun, Yang , Liu, Qinying et al. Green Late-Stage Functionalization of Tryptamines . | CHEMISTRY-A EUROPEAN JOURNAL , 2024 , 30 (46) . |
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