A　pH-responsive　controlled　release　system　is　proposed　using　acid-decomposable　layered　double　hydroxides　(LDHs)　as　inorganic　nanovalves　by　virtue　of　the　electrostatic　adsorption　of　LDH　nanosheets　on　the　surface　of　mesoporous　silica　nanoparticles　(MSNs).　Guest　molecules　(Ru(bpy)(3)Cl-2　in　this　case)　are　loaded　and　encapsulated　in　a　neutral　environment.　The　dissolution　of　the　LDH　coatings　in　an　acidic　environment　triggers　the　release　of　the　guest　molecules　from　the　MSNs.