Photophysical　photochemical　properties,　in　vitro　photodynamic　anticancer　activity　and　interaction　with　albumin　of　a　new　axially　modified　silicon　phthalocyanine,　i.e.　di　(　2-amino-6-trifluoromethyl-4-pyrimidinyloxy)　silicon　phthalocyanine　(SiPcF),　were　studied　in　the　present　paper.　The　Q　band　maximum　absorption　of　SiPcF　located　at　686　nm　with　the　molar　absorption　coefficient　of　2.3　x　10(5)　mol(-1)　.　L　.　cm(-1).　The　fluorescence　emission　of　SiPcF　peaked　at　694　nm　with　a　fluorescence　quantum　yield　of　0.46.　Its　singlet　oxygen　quantum　yield　produced　by　photosensitization　is　0.38,　suggesting　that　SiPcF　is　an　effective　O-1(2)　photosensitizer.　There　is　strong　interaction　between　SiPcF　and　bovine　serum　albumin　(BSA).　The　binding　constant　is　4.33　x　10(5)　mol　.　L-1　and　the　number　of　binding　sites　is　1.　In　vitro　experiments　show　that　SiPcF　had　a　high　photodynamic　anticancer　activity　against　human　hepatoma　cells　HepG2　with　an　IC50　value　down　to　5　x　10(-7)　mol　.　L-1.