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学者姓名：沈小敏
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Abstract ：
本文合成并表征了一种轴向核苷修饰硅酞菁，即二[5′-（2′,3′-O-异丙基）-6-氯嘌呤核苷氧基]硅酞菁（SP1）。通过紫外吸收光谱和荧光光谱研究表明，该化合物在N,N-二甲基甲酰胺和含1%Cremophor EL水溶液中以单体形式存在。该化合物具有较高的单线态氧，具有显著的光动力抗癌活性，对人体肝癌细胞HepG2的半致死浓度（IC_(50)）低至0.2×10~(-6)mol·L~(-1)。荧光共聚焦显微镜研究显示，SP1可定位于细胞线粒体中。研究表明，该化合物SP1是一种有发展潜力的抗癌光敏剂。
Keyword ：
光动力治疗 光动力治疗 抗癌活性 抗癌活性 核苷 核苷 硅酞菁 硅酞菁
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| GB/T 7714 | 沈小敏 . 轴向核苷修饰硅酞菁的合成与光动力活性 [J]. | 化学工程师 , 2024 , 38 (03) : 6-10 . |
| MLA | 沈小敏 . "轴向核苷修饰硅酞菁的合成与光动力活性" . | 化学工程师 38 . 03 (2024) : 6-10 . |
| APA | 沈小敏 . 轴向核苷修饰硅酞菁的合成与光动力活性 . | 化学工程师 , 2024 , 38 (03) , 6-10 . |
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A stereoselective pyridinium hexafluorophosphate-catalyzed C-glycosylation of indole is presented, featuring the plausible formation of a catalyst-acceptor complex and a crucial H-bond between the N-H group of indole and the oxygen atom at the C6 position of the glycosyl donor, which are proposed to collectively facilitate the glycosylation process. This reaction proceeds under mild conditions, enabling the selective synthesis of a wide range of C-indolyl glycosides.
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| GB/T 7714 | Xie, Lihuang , Liu, Wenchao , Guo, Zhenbo et al. A stereoselective organocatalyzed C-glycosylation of indole: implications of acceptor-catalyst-donor interactions [J]. | ORGANIC CHEMISTRY FRONTIERS , 2024 , 12 (2) : 509-515 . |
| MLA | Xie, Lihuang et al. "A stereoselective organocatalyzed C-glycosylation of indole: implications of acceptor-catalyst-donor interactions" . | ORGANIC CHEMISTRY FRONTIERS 12 . 2 (2024) : 509-515 . |
| APA | Xie, Lihuang , Liu, Wenchao , Guo, Zhenbo , Jiao, Qinbo , Shen, Xiaomin , Liu, Tianfei et al. A stereoselective organocatalyzed C-glycosylation of indole: implications of acceptor-catalyst-donor interactions . | ORGANIC CHEMISTRY FRONTIERS , 2024 , 12 (2) , 509-515 . |
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A series of new silicon(IV) phthalocyanines (SiPcs) di-substituted axially with different nucleoside moieties have been synthesized and evaluated for their singlet oxygen quantum yields (Phi(Delta)) and in vitro photodynamic activities. The adenosine-substituted SiPc shows a lower photosensitizing efficiency (Phi(Delta) = 0.35) than the uridine- and cytidine-substituted analogs (Phi(Delta) = 0.42-0.44), while the guanosine-substituted SiPc exhibits a weakest singlet oxygen generation efficiency with a Phi(Delta) value down to 0.03. On the other hand, replacing axial adenosines with chloro-modified adenosines and purines can result in the increase of photogenerating singlet oxygen efficiencies of SiPcs. The formed SiPcs 1 and 2, which contain monochloro-modified adenosines and dichloro-modified purines respectively, appear as efficient photosensitizers with Phi(Delta) of 0.42-0.44. Both compounds I and 2 present high photocytotoxicities against HepG2 and BGC823 cancer cells with IC50 values ranging from 9 nM to 33 nM. The photocytotoxicities of these two compounds are remarkably higher than the well-known anticancer photo sensitizer, chlorin e6 (IC50 = 752 nM against HepG2 cells) in the same condition. As revealed by confocal microscopy, for both cell lines, compound I can essentially bind to mitochondria, while compound 2 is just partially localized in mitochondria. In addition, the two compounds induce cell death of HepG2 cells likely through apoptosis. (C) 2016 Elsevier B.V. All rights reserved.
Keyword ：
Nucleoside Nucleoside Photodynamic therapy Photodynamic therapy Photosensitizer Photosensitizer Silicon(IV) phthalocyanine Silicon(IV) phthalocyanine Singlet oxygen quantum yields Singlet oxygen quantum yields
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| GB/T 7714 | Zheng, Bi-Yuan , Shen, Xiao-Min , Zhao, Dong-Mei et al. Silicon(IV) phthalocyanines substituted axially with different nucleoside moieties. Effects of nucleoside type on the photosensitizing efficiencies and in vitro photodynamic activities [J]. | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY , 2016 , 159 : 196-204 . |
| MLA | Zheng, Bi-Yuan et al. "Silicon(IV) phthalocyanines substituted axially with different nucleoside moieties. Effects of nucleoside type on the photosensitizing efficiencies and in vitro photodynamic activities" . | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 159 (2016) : 196-204 . |
| APA | Zheng, Bi-Yuan , Shen, Xiao-Min , Zhao, Dong-Mei , Cai, Yi-Bin , Ke, Mei-Rong , Huang, Jian-Dong . Silicon(IV) phthalocyanines substituted axially with different nucleoside moieties. Effects of nucleoside type on the photosensitizing efficiencies and in vitro photodynamic activities . | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY , 2016 , 159 , 196-204 . |
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通过荧光光谱法研究了5种轴向核苷(胞苷、氮杂胞苷、甲基胞苷、尿苷和甲基尿苷)衍生物修饰硅酞菁与牛血清白蛋白(BSA)的相互作用,结果表明,它们与BSA存在较强的相互作用,结合常数在(4.90~83.18)×105 mol-1·L之间。因此,进一步制备了二[5’-(2’,3’-O-异丙基)-胞苷氧基]硅酞菁(SiPc1)与BSA的非共价复合物(SiPc1-BSA),复合物中两者的摩尔比为1∶1。SiPc1-BSA与SiPc1在可见区的吸收光谱没有明显区别,两者的Q带最大吸收带均位于686nm附近,且吸收强度没有明显区别,这说明SiPc1结合到白蛋白后,其光谱性质没有受到明显改变。光动力抗癌活性测...
Keyword ：
光动力治疗 光动力治疗 核苷 核苷 白蛋白 白蛋白 硅酞菁 硅酞菁 非共价复合物 非共价复合物
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| GB/T 7714 | 杨晓梅 , 郑碧远 , 蔡悦 et al. 轴向核苷修饰硅酞菁与白蛋白非共价复合物的制备与光动力活性 [J]. | 光谱学与光谱分析 , 2015 , 35 (02) : 457-461 . |
| MLA | 杨晓梅 et al. "轴向核苷修饰硅酞菁与白蛋白非共价复合物的制备与光动力活性" . | 光谱学与光谱分析 35 . 02 (2015) : 457-461 . |
| APA | 杨晓梅 , 郑碧远 , 蔡悦 , 林爱兰 , 沈小敏 , 张汉辉 et al. 轴向核苷修饰硅酞菁与白蛋白非共价复合物的制备与光动力活性 . | 光谱学与光谱分析 , 2015 , 35 (02) , 457-461 . |
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本文通过荧光光谱法研究了3种轴向胞苷衍生物(胞苷(C)、氮杂胞苷(Cn)和甲基胞苷(Cm))修饰硅酞菁与牛血清白蛋白(BSA)的相互作用，结果表明，它们与BSA存在较强的相互作用，结合常数在(4.90～83.18)×105 mol-1·L之间.
Keyword ：
光动力治疗 光动力治疗 核苷 核苷 白蛋白 白蛋白 硅酞菁 硅酞菁 非共价复合物 非共价复合物
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| GB/T 7714 | 郑碧远 , 杨晓梅 , 沈小敏 et al. 胞苷衍生物修饰硅酞菁与白蛋白非共价复合物的制备与光动力活性 [C] //福建省药学会药剂专业委员会2015年学术年会论文集 . 2015 : 224-224 . |
| MLA | 郑碧远 et al. "胞苷衍生物修饰硅酞菁与白蛋白非共价复合物的制备与光动力活性" 福建省药学会药剂专业委员会2015年学术年会论文集 . (2015) : 224-224 . |
| APA | 郑碧远 , 杨晓梅 , 沈小敏 , 黄剑东 . 胞苷衍生物修饰硅酞菁与白蛋白非共价复合物的制备与光动力活性 福建省药学会药剂专业委员会2015年学术年会论文集 . (2015) : 224-224 . |
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The pyrene-appended dipicolylamine ligand (L) and its Cu(II) and Pt(II) compounds have been synthesized and characterized by elemental analysis, H-1- and C-13-NMR, HRMS, FT-IR andUV-Vis analyses. Furthermore, the crystal structures of H2L center dot 2ClO(4), [(CuLClO4CH3CN)ClO4] and [(PtLCl)DMSO] (DMSO = dimethyl sulfoxide) have been determined by single-crystal X-ray diffraction. The antimicrobial activities of these compounds were determined towards Gram-positive (Staphylococcus aureus ATCC-25923) and Gram-negative (Escherichia coli ATTC-25922) trains of bacteria, as well as the fungal strain Candida albicans ATCC-10213, and the results were compared with those of L alone. The results of these experiments showed that the Cu(II) and Pt(II) compounds of L exhibited stronger antibacterial and antifungal activities than the ligand.
Keyword ：
Antibacterial activity Antibacterial activity Crystal structure Crystal structure Dipicoclylamine ligand Dipicoclylamine ligand Metal compound Metal compound Synthesis Synthesis
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| GB/T 7714 | Yuan, Ze-Li , Wang, Lei , Shen, Xiao-Min et al. Copper(II) and platinum(II) compounds with pyrene-appended dipicolylamine ligand: syntheses, crystal structures and biological evaluation [J]. | JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY , 2015 , 82 (1-2) : 135-143 . |
| MLA | Yuan, Ze-Li et al. "Copper(II) and platinum(II) compounds with pyrene-appended dipicolylamine ligand: syntheses, crystal structures and biological evaluation" . | JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY 82 . 1-2 (2015) : 135-143 . |
| APA | Yuan, Ze-Li , Wang, Lei , Shen, Xiao-Min , Yang, Xiao-Qing , Huang, Jian-Dong , Wei, Gang . Copper(II) and platinum(II) compounds with pyrene-appended dipicolylamine ligand: syntheses, crystal structures and biological evaluation . | JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY , 2015 , 82 (1-2) , 135-143 . |
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Molecular conformation is an important issue related to the self-assembly architecture and property. The self-assembly of silicon(IV) phthalocyanines covalently linked to the 5-N-cytidine or 4-carboxyphenoxy moiety at the axial positions, namely, SiPc(NC)(2) and SiPc(CP)(2), respectively, has been studied by means of scanning tunneling microscopy (STM) at the solid-liquid interface. The intermolecular axial hydrogen bonding in combination with the stabilizing role of the TCDB template brings about supramolecular selfassembled structures of silicon(IV) phthalocyanines in an edge-on orientation. Two pyridine compounds, 4,4'-bipyridine (BPY) and 1,2-di(4-pyridy0ethylene (DPE), can tune the supramolecular structure, leading to interestingly axial self-assemblies of SiPc(CP)(2) with BPY and DPE in an edge-on manner by hydrogen bonding. The results indicate that the axial substituents and the axial ligands can regulate and precisely control the conformation and arrangement of the phthalocyanine moiety on the graphite surface.
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| GB/T 7714 | Geng, Yanfang , Xu, Jing , Xue, Jindong et al. Study of the Edge-on Self-Assembly of Axially Substituted Silicon(IV) Phthalocyanine Derivatives in a Template on the HOPG Surface [J]. | LANGMUIR , 2015 , 31 (49) : 13394-13401 . |
| MLA | Geng, Yanfang et al. "Study of the Edge-on Self-Assembly of Axially Substituted Silicon(IV) Phthalocyanine Derivatives in a Template on the HOPG Surface" . | LANGMUIR 31 . 49 (2015) : 13394-13401 . |
| APA | Geng, Yanfang , Xu, Jing , Xue, Jindong , Shen, Xiaomin , Li, Min , Huang, Jiandong et al. Study of the Edge-on Self-Assembly of Axially Substituted Silicon(IV) Phthalocyanine Derivatives in a Template on the HOPG Surface . | LANGMUIR , 2015 , 31 (49) , 13394-13401 . |
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The interactions of bovine serum albumin (BSA) with five novel silicon (IV) phthalocyanines(SiPc1-5) axially modified by nucleosides (cytidine, 5-N-cytidine, methyl cytidine, uridine and methyl uridine) derivatives were studied by fluorescence spectroscopy. The results show that there are strong interactions between these silicon phthalocyanines and BSA with a binding constant of(4. 90 similar to 83. 18) x10(5) mol(-1) . L. Therefore, the non-covalent BSA conjugate of bis(2',3'-O-isopropyl-cytidine-oxy) phthalocyaninatosilicon(IV) (SiPc1) was further been prepared. The molar ratio of phthalocyanine to albumin was found to be 1 : 1 for the obtained SiPc1-BSA conjugate. The absorption spectra of SiPc1 and SiPc1-BSA in the visible region have no significant difference, both showing an Q-band maximum at about 686 inn. It indicates that the spectroscopic characteristics of SiPc1 are not affected by binding to albumin. The SiPc1-BSA conjugate exhibits high photodynamic activity against human hepatoma cell line HepG2 with an IC50 value of 3. 0x10(-7) mol . L-1. By comparsion, SiPc1-BSA has a higher photodynamic activity than SiPc1 (in PBS formation, IC50=7. 0x10(-7) mol . L-1), which can be attributed to its higher cellular uptake.
Keyword ：
Albumin Albumin Non-covalent conjugate Non-covalent conjugate Nucleoside Nucleoside Photodynamic activity Photodynamic activity Silicon phthalocyanine Silicon phthalocyanine
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| GB/T 7714 | Yang Xiao-mei , Zheng Bi-yuan , Cai Yue et al. Non-Covalent Albumin Conjugates of Silicon(IV) Phthalocyanines Axially Substituted with Nucleoside: Preparation and in vitro Photodynamic Activities [J]. | SPECTROSCOPY AND SPECTRAL ANALYSIS , 2015 , 35 (2) : 457-461 . |
| MLA | Yang Xiao-mei et al. "Non-Covalent Albumin Conjugates of Silicon(IV) Phthalocyanines Axially Substituted with Nucleoside: Preparation and in vitro Photodynamic Activities" . | SPECTROSCOPY AND SPECTRAL ANALYSIS 35 . 2 (2015) : 457-461 . |
| APA | Yang Xiao-mei , Zheng Bi-yuan , Cai Yue , Lin Ai-lan , Shen Xiao-min , Zhang Han-hui et al. Non-Covalent Albumin Conjugates of Silicon(IV) Phthalocyanines Axially Substituted with Nucleoside: Preparation and in vitro Photodynamic Activities . | SPECTROSCOPY AND SPECTRAL ANALYSIS , 2015 , 35 (2) , 457-461 . |
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Three coordination polymers based on a tridentate N-3-coordinated anthracene-containing tripodal ligand, 9-[(2,2'-dipicolylamino) methyl]anthracene (ADPA), namely [Cu(ADPA)Cl-2]center dot H2O (1), [Ru(ADPA)Cl-2-DMSO]center dot 4CH(3)OH center dot 2H(2)O (2), and [Pt(ADPA)Cl]PF6 center dot DMSO center dot 2CH(3)OH center dot H2O (3), were synthesized and characterized using elemental analysis, H-1 NMR, C-13 NMR, FT-IR, and UV-vis spectroscopies, H RMS, and single-crystal XRD. X-ray structural analysis showed that the three compounds have mononuclear, 0D structures, which are further connected by hydrogen bonds into 3D supramolecular architectures. The antimicrobial activities of ADPA and compounds 1-3 were evaluated based on the minimum inhibitory concentration and minimum bactericidal concentration. The results showed that compounds 1-3 exhibit significant activities against Gram-positive bacteria (Staphylococcus aureus), and the Ru(II) and Pt(II) compounds have moderate antifungal activities (Candida albicans).
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| GB/T 7714 | Yuan, Zeli , Shen, Xiaomin , Huang, Jiandong . Syntheses, crystal structures and antimicrobial activities of Cu(II), Ru(II), and Pt(II) compounds with an anthracene-containing tripodal ligand [J]. | RSC ADVANCES , 2015 , 5 (14) : 10521-10528 . |
| MLA | Yuan, Zeli et al. "Syntheses, crystal structures and antimicrobial activities of Cu(II), Ru(II), and Pt(II) compounds with an anthracene-containing tripodal ligand" . | RSC ADVANCES 5 . 14 (2015) : 10521-10528 . |
| APA | Yuan, Zeli , Shen, Xiaomin , Huang, Jiandong . Syntheses, crystal structures and antimicrobial activities of Cu(II), Ru(II), and Pt(II) compounds with an anthracene-containing tripodal ligand . | RSC ADVANCES , 2015 , 5 (14) , 10521-10528 . |
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合成了一种轴向核苷修饰硅酞菁,即二[5′-(2′,3′-O-异丙基)-5-甲基胞苷氧基]硅酞菁,并通过1 H NMR和HR-MS等手段进行了表征。该化合物在N,N-二甲基甲酰胺和含1%Cremophor EL水溶液中以单体形式存在,Q带最大吸收波长分别位于676和679nm,荧光发射峰分别位于685和689nm。离体光动力抗癌活性表明,该化合物具有显著的光动力抗癌活性,对人肝癌细胞HepG2的半致死浓度(IC50)低至7.8×10-8 mol·L-1。荧光共聚焦显微镜研究显示,SiPcG可定位于细胞线粒体中。研究表明,SiPcG是一种有发展潜力的新型抗癌光敏剂。
Keyword ：
光动力抗癌活性 光动力抗癌活性 合成 合成 核苷 核苷 硅酞菁 硅酞菁
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| GB/T 7714 | 沈小敏 , 郑碧远 , 张汉辉 et al. 一种轴向核苷修饰硅酞菁的合成与光动力抗癌活性 [J]. | 光谱学与光谱分析 , 2013 , 33 (10) : 2731-2735 . |
| MLA | 沈小敏 et al. "一种轴向核苷修饰硅酞菁的合成与光动力抗癌活性" . | 光谱学与光谱分析 33 . 10 (2013) : 2731-2735 . |
| APA | 沈小敏 , 郑碧远 , 张汉辉 , 黄剑东 . 一种轴向核苷修饰硅酞菁的合成与光动力抗癌活性 . | 光谱学与光谱分析 , 2013 , 33 (10) , 2731-2735 . |
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