The　therapeutic　concentration　of　cisplatin　(CDDP)　is　usually　associated　with　dose-limiting　side　effects.　To　avoid　these　harmful　effects,　a　biocompatible　hydrogel　carrier　which　consisted　of　poly(N-isopropylacrylamide)　and　carboxymethyl　chitosan　was　designed　to　deliver　CDDP　to　the　local　environment　of　a　solid　tumor.　The　poly(N-isopropylacrylamide)-g-carboxymethyl　chitosan　hydrogels　were　synthesized　by　chemical　crosslinking.　Scanning　electronic　microscopy　images　showed　that　the　hydrogels　exhibited　a　cross-linked　structure　with　the　average　pore　size　from　100　to　200　A　mu　m.　Water　contact　angles　and　swelling　studies　suggested　that　the　hydrogels　had　good　hydrophilicity　and　the　lower　critical　solution　temperature　lay　in　the　vicinity　of　32　A　degrees　C.　The　MTT　assays　implied　that　the　hydrogels　were　non-cytotoxic　on　NIH3T3　cells.　In　vitro　release　experiment　demonstrated　that　the　release　of　CDDP　was　controllable　and　sustained　over　a　long　period.　Moreover,　the　released　CDDP　retained　its　anticancer　activity　on　A549　cells.　The　hydrogels　are　promising　carriers　for　sustained　release　of　cisplatin.