The　therapeutic　concentration　of　cisplatin　(CDDP)　is　usually　associated　with　dose-limiting　side　effects.　To　avoid　these　harmful　effects,　a　biocompatible　hydrogel　carrier　which　consisted　of　poly(N-isopropylacrylamide)　and　carboxymethyl　chitosan　was　designed　to　deliver　CDDP　to　the　local　environment　of　a　solid　tumor.　The　poly(N-isopropylacrylamide)-g-carboxymethyl　chitosan　hydrogels　were　synthesized　by　chemical　crosslinking.　Scanning　electronic　microscopy　images　showed　that　the　hydrogels　exhibited　a　cross-linked　structure　with　the　average　pore　size　from　100　to　200 µm.　Water　contact　angles　and　swelling　studies　suggested　that　the　hydrogels　had　good　hydrophilicity　and　the　lower　critical　solution　temperature　lay　in　the　vicinity　of　32 °C.　The　MTT　assays　implied　that　the　hydrogels　were　non-cytotoxic　on　NIH3T3　cells.　In　vitro　release　experiment　demonstrated　that　the　release　of　CDDP　was　controllable　and　sustained　over　a　long　period.　Moreover,　the　released　CDDP　retained　its　anticancer　activity　on　A549　cells.　The　hydrogels　are　promising　carriers　for　sustained　release　of　cisplatin.　©　2015,　Springer　Science+Business　Media　New　York.