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author:

Wei, Jian Chong (Wei, Jian Chong.) [1] | Gao, Yue Ming (Gao, Yue Ming.) [2] (Scholars:高跃明) | Li, Guo Qing (Li, Guo Qing.) [3] | Wang, Zhi Jiong (Wang, Zhi Jiong.) [4] | Vai, Mang I. (Vai, Mang I..) [5] | Mak, Peng Un (Mak, Peng Un.) [6] | Du, Min (Du, Min.) [7] | Pun, Sio Hang (Pun, Sio Hang.) [8]

Indexed by:

Scopus SCIE

Abstract:

Lateral flow immunochromatographic assay (LFIA) testing is essential for accurate detection and diagnoses of diseases and physical conditions. However, the existing LFIA strip reader equipped with high cost of hardware confines its simplicity and portability. Therefore, this study develops a simple, low cost LFIA strip reader comprising 4 major modules - mechanical, optical, processing and control modules. The mechanical module pulls in and out the test strip automatically to be read by the optical module and the data processing module provides the test results by analyzing the data sent by the optical module. All the individual modules are controlled by a control module. To reduce the hardware budget and control complexity, a time-triggered cooperative (TTC) scheduler implemented on an 8051 IP core was chosen as control system. In addition, special, high sensitivity C-reactive protein (CRP) strips with 10 different concentrations were tested to evaluate the performance of the system. Further, a commercial ESEQuant lateral flow reader (QIAGEN, Germany) was tested as a comparative study. The test results show that the proposed reader was stable with a coefficient of variation (CV) factor within 3%. To test the qualitative performance of the system, each of the CRP concentration were examined for 10 times, which indicates that the system has a large dynamic detection range and good detection linearity (R-2 = 0.998). In short, the proposed LFIA strip reader has high potential relative to existing readers, especially in simplicity and cost.

Keyword:

8051 IP Core Lateral flow immunochromatographic assay (LFIA) Scheduler Strip reader

Community:

  • [ 1 ] [Wei, Jian Chong]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou, Fujian, Peoples R China
  • [ 2 ] [Wang, Zhi Jiong]Biomed Engn Lab, Macau, Peoples R China
  • [ 3 ] [Wang, Zhi Jiong]State Key Lab Analog & Mixed Signal VLSI, Macau, Peoples R China
  • [ 4 ] [Pun, Sio Hang]Univ Macau, State Key Lab Analog & Mixed Signal VLSI, Macau, Peoples R China
  • [ 5 ] [Gao, Yue Ming]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou, Fujian, Peoples R China
  • [ 6 ] [Vai, Mang I.]Univ Macau, Fac Sci & Technol, Dept Elect & Comp Engn, Macau, Macau, Peoples R China
  • [ 7 ] [Mak, Peng Un]Univ Macau, Dept Elect & Comp Engn, Fac Sci & Technol, Biomed Engn Lab, Room 3037,Bldg E11,HengQin HQ Campus, Macau, Macau, Peoples R China

Reprint 's Address:

  • 高跃明

    [Gao, Yue Ming]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou, Fujian, Peoples R China

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Source :

AUTOMATIKA

ISSN: 0005-1144

Year: 2016

Issue: 4

Volume: 57

Page: 1079-1088

0 . 3 8

JCR@2016

1 . 7 0 0

JCR@2023

ESI Discipline: ENGINEERING;

ESI HC Threshold:177

JCR Journal Grade:4

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 2

SCOPUS Cited Count: 2

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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