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Abstract：
Chemodynamic therapy (CDT) utilizes iron-initiated Fenton chemistry to destroy tumor cells by converting endogenous H2O2 into the highly toxic hydroxyl radical ((OH)-O-.). There is a paucity of Fenton-like metal-based CDT agents. Intracellular glutathione (GSH) with center dot OH scavenging ability greatly reduces CDT efficacy. A self-reinforcing CDT nanoagent based on MnO2 is reported that has both Fenton-like Mn2+ delivery and GSH depletion properties. In the presence of HCO3-, which is abundant in the physiological medium, Mn2+ exerts Fenton-like activity to generate center dot OH from H2O2. Upon uptake of MnO2-coated mesoporous silica nanoparticles (MS@MnO2 NPs) by cancer cells, the MnO2 shell undergoes a redox reaction with GSH to form glutathione disulfide and Mn2+, resulting in GSH depletion-enhanced CDT. This, together with the GSH-activated MRI contrast effect and dissociation of MnO2, allows MS@MnO2 NPs to achieve MRI-monitored chemo-chemodynamic combination therapy.
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN： 1433-7851
Year： 2018
Issue： 18
Volume： 57
Page： 4902-4906
1 2 . 2 5 7
JCR@2018
1 6 . 1 0 0
JCR@2023
ESI Discipline： CHEMISTRY;
ESI HC Threshold：209
JCR Journal Grade：1
CAS Journal Grade：2
Cited Count：
WoS CC Cited Count： 1124
SCOPUS Cited Count： 1145
ESI Highly Cited Papers on the List： 33 Unfold All
WanFang Cited Count：
Chinese Cited Count：
30 Days PV： 3
Affiliated Colleges：
