In　a　magnetic　hyperthermia　treatment,　malignant　cells　are　ablated　by　the　heat　produced　by　power　dissipation　of　magnetic　nanoparticles　(MNPs)　under　an　alternating　magnetic　field.　MNPs　need　to　be　placed　inside　the　tumor　region　and　a　prominent　method　for　doing　this　is　to　inject　magnetic　fluid　directly　into　tumor.　When　this　alternative　is　used,　the　efficiency　of　a　magnetic　hyperthermia　treatment　depends　on　factors　such　as　the　infusion　rate　and　diffusion　duration,　since　they　affect　the　shape　of　MNP　distribution　inside　tumor,　which　affects　the　temperature　distribution　during　treatment.　This　paper　analyzes　the　impact　of　different　shapes　of　MNP　distribution,　caused　by　different　infusion　rates,　on　mass　diffusion　and　treatment　temperature　field　during　magnetic　hyperthermia.　Three　different　shapes　of　MNP　distribution　were　assumed　based　on　images　of　experiments　presented　in　literature,　which　used　an　agarose　gel　with　different　concentrations　to　represent　different　tissues.　In　addition,　the　distribution　for　a　very　low　infusion　rate,　obtained　from　a　model　proposed　in　this　paper,　is　used　for　comparison　purposes.　A　proposed　geometric　model　is　used　to　numerically　evaluate　the　impact　of　injection　and　diffusion　parameters　on　a　liver　tumor　considering　the　four　different　shapes　of　MNPs　produced　by　different　infusion　rates.　The　simulation　results　demonstrate　that　the　longer　the　diffusion　duration　and　the　larger　the　infusion　rate　are,　the　better　the　therapeutic　effects　are　when　a　proper　power　dissipation　of　MNPs　is　used　to　control　the　maximum　temperature　reached　during　hyperthermia.　To　further　improve　the　effective　therapeutic　area　inside　tumor,　two　alternative　methods　are　also　evaluated　using　the　model　proposed　in　this　paper:　multi-site　injection　and　low　Curie　temperature　MNPs.　The　results　show　that　both　of　them　can　significantly　improve　the　tumor　area　which　is　subjected　to　the　therapeutic　temperature,　especially　the　latter　one.　(C)　2018　Elsevier　Ltd.　All　rights　reserved.