Magnetic　nanoparticle-(MNP)　hyperthermia　ablates　malignant　cells　by　heating　the　region　of　interest　when　MNPs　are　subjected　to　an　external　alternating　magnetic　field.　The　energy　density　to　be　dissipated　into　heat,　and　consequently　the　temperature　profile　during　treatment,　depends　on　the　distribution　of　MNPs　within　the　tumoral　region.　This　paper　uses　numerical　models　to　evaluate-the　temporal　and　spatial　temperature　distributions　inside　a　tumor　when　intratumoral　injection　of　MNPs　is　considered.　To　this　end,　the　theories　of　mass　transfer　and　diffusion　in　interstitial　tissue　ate　combined　with　Rosensweig＇s　theory　and　Pennes　bio-heat　transfer　equation,　and　the　finite　element　method　is　used　for　analyzing　the　temperature　field　under　different　scenarios.　Simulation　results　demonstrate　that　the　treatment　temperature　field　strongly　depends　on　factors,　such　as　(lie　injection　method,　particle-size,　injection　concentration　and　injection　dose.　However,　the　maximal　temperature　reached　during　hyperthermia　and　the　effective　treatment　area　are　difficult　to　control.　In　order　to　obtain　better　treatment　effects,　this　paper　investigates　a　solution　that　uses　a　kind　of　material　with　low　Curie　temperature-and　the　results　show　that　the　effective　treatment　area　of　hyperthermia　can　be　significantly　improved　using　this　type　of　MNP.