Structural　heterogeneity　is　a　common　phenomenon　in　cellulose　hydrogel　fabricated　from　ionic　liquid.　In　this　work,　we　characterized　cellulose　hydrogel　wire　by　Fourier　transform　infrared　spectroscopy　(FTIR)　image　system　and　found　its　interesting　core-shell　structure.　By　pixel　spectra　analysis,　we　explored　their　distinctive　hydrogen　bond　network　in　core　and　shell　regions.　To　unveil　the　formation　of　heterogeneous　core-shell　structure,　we　tracked　the　cellulose　regeneration　procedure　in　situ　by　time-dependent　attenuated　total　reflection　Fourier　transform　infrared　(ATR-FTIR)　spectroscopy.　Inspired　by　an　interesting　red　followed　by　blue　band　position　shift,　namely　＂V-shape＂　shift,　we　proposed　a　tri-step　model　of　cellulose　regeneration　in　favor　of　quantum　calculation.　The　tri-step　model　can　explain　the　formation　of　the　heterogeneous　core-shell　structure.