A　double　nucleophilic　addition-cyclization-elimination　cascade　is　developed,　that　allows　various　2,6-diaryl-4-perfluoroalkylpyridines　to　be　synthesized　in　one　step　from　easily　available　enamides　and　perfluorocarboxylic　anhydrides.　The　procedure　is　also　operationally　simple　and　scalable　and　provides　access　to　the　facial　construction　of　4-fluoroalkylpyridines,　which　are　of　great　interest　in　medicinal　chemistry.