Malignant　cells　can　be　ablated　by　a　specific　treatment　temperature　during　magnetic　hyperthermia,　which　is　induced　by　the　power　dissipation　of　magnetic　nanoparticles　(MNPs)　inside　tumor　region　under　an　alternating　magnetic　field.　MNPs　contained　in　nanofluid　need　to　be　transferred　to　tumor　region　before　therapy　can　begin,　and　one　of　the　most　prominent　methods　is　direct　injection.　Although　different　aspects　of　this　area　are　covered　in　literature,　the　study　of　models　which　consider　the　combined　effects　of　nanofluid　transport　and　heat　generation　on　the　ablation　of　malignant　cells　still　lacks　enough　attention.　A　complete　computational　model　is　developed　in　this　paper　to　evaluate　the　survival　rate　of　malignant　cells　for　a　proposed　geometric　model　when　intratumoral　injection　of　MNPs　is　considered.　The　mathematical　model　incorporates　the　transport　of　nanofluid　inside　the　bio-tissue,　the　heat　generation　of　MNPs　during　ablation,　the　heat　transfer　of　bio-tissue,　and　the　cell　death　probability　based　on　the　Arrhenius　model.　The　concentration　distribution　of　nanofluid　and　the　treatment　temperature　profile　inside　bio-tissue　are　obtained　by　considering　the　finite　element　method　with　the　proposed　boundary　and　initial　conditions.　Simulation　results　demonstrate　that　the　death　rate　of　malignant　cells　can　be　considerably　improved　when　a　proper　critical　power　dissipation　of　MNPs　is　designed　and　enough　diffusion　duration　is　considered　for　therapy.　With　further　developments,　the　model　may　be　used　for　the　planning　of　magnetic　hyperthermia.　(C)　2020　Elsevier　Inc.　All　rights　reserved.