Poly(vinylidene　fluoride)　(PVDF)-based　piezoelectric　materials　have　emerged　as　a　transformative　platform　in　tissue　engineering　due　to　their　unique　ability　to　mimic　endogenous　bioelectric　signals,　which　play　pivotal　roles　in　cellular　behaviors,　such　as　proliferation,　differentiation,　and　tissue　regeneration.　This　review　comprehensively　explores　the　structural　polymorphism,　processing　techniques,　and　electromechanical　properties　of　PVDF　and　its　copolymers,　emphasizing　their　superior　piezoelectric　coefficients,　biocompatibility,　and　adaptability　to　diverse　fabrication　methods.　The　intrinsic　piezoelectricity　of　PVDF,　driven　by　its　polar　β-phase,　enables　dynamic　responses　to　mechanical　stimuli,　such　as　physiological　movements　or　external　forces,　generating　localized　electrical　potentials　that　modulate　critical　signaling　pathways　to　enhance　tissue　repair.　Applications　span　multiple　organs:　in　bone　regeneration,　PVDF　scaffolds　promote　osteogenesis　through　mechanoelectrical　coupling;　in　neural　engineering,　they　facilitate　axonal　growth　and　myelination;　in　cardiac　repair,　they　synchronize　cardiomyocyte　contraction;　and　in　skin　healing,　they　accelerate　re-epithelialization　and　angiogenesis.　Despite　these　advances,　challenges　persist,　including　optimizing　piezoelectric　output,　ensuring　long-term　biocompatibility,　and　achieving　controlled　biodegradability.　Future　directions　highlight　the　integration　of　PVDF　with　smart　functionalities　and　the　exploration　of　organ-specific　signaling　mechanisms　to　advance　clinical　translation.　This　work　underscores　the　potential　of　PVDF-based　materials　as　multifunctional　platforms　for　next-generation　regenerative　therapies.　©　2025　Author(s).