Flexible　electronic　skin　(E-skin)　sensors　offer　innovative　solutions　for　detecting　human　body　signals,　enabling　human-machine　interactions　and　advancing　the　development　of　intelligent　robotics.　Electrospun　nanofibers　are　particularly　well-suited　for　E-skin　applications　due　to　their　exceptional　mechanical　properties,　tunable　breathability,　and　lightweight　nature.　Nanofiber-based　composite　materials　consist　of　three-dimensional　structures　that　integrate　one-dimensional　polymer　nanofibers　with　other　functional　materials,　enabling　efficient　signal　conversion　and　positioning　them　as　an　ideal　platform　for　next-generation　intelligent　electronics.　Here,　this　review　begins　with　an　overview　of　electrospinning　technology,　including　far-field　electrospinning,　near-field　electrospinning,　and　melt　electrospinning.　It　also　discusses　the　diverse　morphologies　of　electrospun　nanofibers,　such　as　core-shell,　porous,　hollow,　bead,　Janus,　and　ribbon　structure,　as　well　as　strategies　for　incorporating　functional　materials　to　enhance　nanofiber　performance.　Following　this,　the　article　provides　a　detailed　introduction　to　electrospun　nanofiber-based　composite　materials　(i.e.,　nanofiber/hydrogel,　nanofiber/aerogel,　nanofiber/metal),　emphasizing　their　recent　advancements　in　monitoring　physical,　physiological,　body　fluid,　and　multi-signal　in　human　signal　detection.　Meanwhile,　the　review　explores　the　development　of　multimodal　sensors　capable　of　responding　to　diverse　stimuli,　focusing　on　innovative　strategies　for　decoupling　multiple　signals　and　their　state-of-the-art　advancements.　Finally,　current　challenges　are　analyzed,　while　future　prospects　for　electrospun　nanofiber-based　composite　sensors　are　outlined.　This　review　aims　to　advance　the　design　and　application　of　next-generation　flexible　electronics,　fostering　breakthroughs　in　multifunctional　sensing　and　health　monitoring　technologies.