Significant　advances　have　been　made　in　the　preparation　and　application　of　luminescent　hydrogen-bonded　organic　frameworks　(HOFs)　in　recent　years.　These　materials　exhibit　unique　structural　flexibility　in　accommodating　guest　molecules,　rendering　them　promising　candidates　for　dynamic　applications.　Herein,　a　2D　HOF　material　is　presented,　constructed　by　the　binary　assembly　of　5,5′-bis(azanediyl)oxalyl　diisophthalic　acid　and　tetra(pyrid-4-ylphenyl)ethylene　to　achieve　dynamic　circularly　polarized　luminescence　(CPL)　with　the　aid　of　chiral　guests.　Efficient　chirality　transfer　and　CPLs　are　realized　by　incorporating　chiral　carvone　molecules　into　the　1D　channels　of　HOFs　through　hydrogen　bonding.　As　a　result　of　the　interlayer　contraction　upon　guest　desorption,　these　HOF　materials　display　dynamic　CPLs　with　emission　colors　varying　from　cyan　to　yellow.　The　method　of　the　hydrogen　bonding-enhanced　host-guest　chirality　transfer　in　combination　with　the　guest　desorption-triggered　interlayer　contraction　provides　a　simple　method　to　achieve　dynamic　chiroptical　properties　with　porous　materials.　©　2025　The　Author(s).　Advanced　Science　published　by　Wiley-VCH　GmbH.