Anthraquinone　derivatives,　known　for　their　redox　properties,　are　widely　recognized　as　promising　cathode　materials　for　aluminum-ion　batteries.　This　study　presents　an　environmentally　benign　extraction　of　aloe-emodin　from　aloe　dry　powder,　a　sustainable　and　economically　viable　resource,　using　ferric　chloride　as　an　oxidizing　agent　in　an　acidic　medium.　Emodin　and　its　isomer,　aloe-emodin,　share　a　symmetrical　polycyclic　chemical　architecture　and　carbonyl　functionalities,　but　differ　in　the　position　of　their　hydroxyl　groups.　The　shift　of　a　hydroxyl　group　from　the　aromatic　ring　to　the　methyl　moiety　in　emodin　results　in　aloe-emodin,　enhancing　its　redox　potential.　As　a　cathode　material　in　aluminum-ion　batteries,　aloe-emodin　demonstrates　enhanced　electrochemical　performance　compared　to　emodin,　showcasing　a　high　reversible　specific　capacity　of　85.9　mAh/g　at　50　mA/g,　superior　rate　capability　with　42.0　and　32.0　mAh/g　at　1000　and　2000　mA/g,　respectively,　and　remarkable　long-term　cyclability　with　a　capacity　retention　of　50.3　mAh/g　and　a　Coulombic　efficiency　of　99.05　%　after　6000　cycles　at　1000　mA/g.　These　findings　contribute　to　a　deeper　understanding　of　the　design　principles　for　aluminum-ion　batteries　that　leverage　anthraquinone-based　cathode　materials.　©　2025　Wiley-VCH　GmbH.