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author:

Zang, L. (Zang, L..) [1] | Liu, J. (Liu, J..) [2] | Zhang, H. (Zhang, H..) [3] | Zhu, S. (Zhu, S..) [4] | Zhu, M. (Zhu, M..) [5] | Wang, Y. (Wang, Y..) [6] | Kang, Y. (Kang, Y..) [7] | Chen, J. (Chen, J..) [8] | Xu, Q. (Xu, Q..) [9]

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Scopus

Abstract:

This study developed and evaluated an automatic segmentation model based on the Mamba framework (AM-UNet) for rapid and precise delineation of high-risk clinical target volume (HRCTV) and organs at risk (OARs) in cervical cancer brachytherapy. Using 694 CT scans from 179 cervical cancer patients, the performance of five models (AM-UNet, UNet, DeepLab V3, UNETR and nnU-Net) was compared. The models were assessed using the Dice similarity coefficient (DSC), 95% Hausdorff distance (HD95), and dose-volume index (DVI). AM-UNet achieved mean DSCs of 0.862, 0.937, 0.823, and 0.725 for HRCTV, bladder, rectum, and sigmoid, respectively. Subjective evaluations showed 93.07% of AM-UNet predicted HRCTV were rated as clinically acceptable or needing minor adjustments, with no unacceptable cases. Dosimetric differences between AM-UNet-generated and manually delineated contours were within 1%, highlighting its potential for improving clinical workflows in brachytherapy. © The Author(s) 2025.

Keyword:

Auto-segmentation Brachytherapy Cervical cancer Computed Deep learning

Community:

  • [ 1 ] [Zang L.]Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fujian, Fuzhou, 350011, China
  • [ 2 ] [Liu J.]Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fujian, Fuzhou, 350011, China
  • [ 3 ] [Zhang H.]Department of Radiation Oncology, Fujian Cancer Hospital, Clinical Oncology School of Fujian Medical University, Fujian, Fuzhou, 350011, China
  • [ 4 ] [Zhu S.]College of Computer and Data Science, Fuzhou University, Fuzhou, 350116, China
  • [ 5 ] [Zhu M.]Department of Radiation Oncology, Fujian Cancer Hospital, Clinical Oncology School of Fujian Medical University, Fujian, Fuzhou, 350011, China
  • [ 6 ] [Wang Y.]Department of Radiation Oncology, Fujian Cancer Hospital, Clinical Oncology School of Fujian Medical University, Fujian, Fuzhou, 350011, China
  • [ 7 ] [Kang Y.]Department of Radiation Oncology, Fujian Cancer Hospital, Clinical Oncology School of Fujian Medical University, Fujian, Fuzhou, 350011, China
  • [ 8 ] [Chen J.]Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China
  • [ 9 ] [Xu Q.]Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fujian, Fuzhou, 350011, China

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Source :

Scientific Reports

ISSN: 2045-2322

Year: 2025

Issue: 1

Volume: 15

3 . 8 0 0

JCR@2023

CAS Journal Grade:3

Cited Count:

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SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 0

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