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author:

Zang, Lele (Zang, Lele.) [1] | Liu, Jing (Liu, Jing.) [2] | Zhang, Huiqi (Zhang, Huiqi.) [3] | Zhu, Shitao (Zhu, Shitao.) [4] | Zhu, Mingxuan (Zhu, Mingxuan.) [5] | Wang, Yuqin (Wang, Yuqin.) [6] | Kang, Yaxin (Kang, Yaxin.) [7] | Chen, Jihong (Chen, Jihong.) [8] | Xu, Qin (Xu, Qin.) [9]

Indexed by:

Scopus SCIE

Abstract:

This study developed and evaluated an automatic segmentation model based on the Mamba framework (AM-UNet) for rapid and precise delineation of high-risk clinical target volume (HRCTV) and organs at risk (OARs) in cervical cancer brachytherapy. Using 694 CT scans from 179 cervical cancer patients, the performance of five models (AM-UNet, UNet, DeepLab V3, UNETR and nnU-Net) was compared. The models were assessed using the Dice similarity coefficient (DSC), 95% Hausdorff distance (HD95), and dose-volume index (DVI). AM-UNet achieved mean DSCs of 0.862, 0.937, 0.823, and 0.725 for HRCTV, bladder, rectum, and sigmoid, respectively. Subjective evaluations showed 93.07% of AM-UNet predicted HRCTV were rated as clinically acceptable or needing minor adjustments, with no unacceptable cases. Dosimetric differences between AM-UNet-generated and manually delineated contours were within 1%, highlighting its potential for improving clinical workflows in brachytherapy.

Keyword:

Auto-segmentation Brachytherapy Cervical cancer Computed Deep learning

Community:

  • [ 1 ] [Zang, Lele]Fujian Med Univ, Fujian Canc Hosp, Dept Gynecol, Clin Oncol Sch, Fuzhou 350011, Fujian, Peoples R China
  • [ 2 ] [Liu, Jing]Fujian Med Univ, Fujian Canc Hosp, Dept Gynecol, Clin Oncol Sch, Fuzhou 350011, Fujian, Peoples R China
  • [ 3 ] [Xu, Qin]Fujian Med Univ, Fujian Canc Hosp, Dept Gynecol, Clin Oncol Sch, Fuzhou 350011, Fujian, Peoples R China
  • [ 4 ] [Chen, Jihong]Fujian Med Univ, Fujian Canc Hosp, Clin Oncol Sch, Dept Radiat Oncol, Fuzhou, Peoples R China
  • [ 5 ] [Zhang, Huiqi]Fujian Med Univ, Fujian Canc Hosp, Dept Radiat Oncol, Clin Oncol Sch, Fuzhou 350011, Fujian, Peoples R China
  • [ 6 ] [Zhu, Mingxuan]Fujian Med Univ, Fujian Canc Hosp, Dept Radiat Oncol, Clin Oncol Sch, Fuzhou 350011, Fujian, Peoples R China
  • [ 7 ] [Wang, Yuqin]Fujian Med Univ, Fujian Canc Hosp, Dept Radiat Oncol, Clin Oncol Sch, Fuzhou 350011, Fujian, Peoples R China
  • [ 8 ] [Kang, Yaxin]Fujian Med Univ, Fujian Canc Hosp, Dept Radiat Oncol, Clin Oncol Sch, Fuzhou 350011, Fujian, Peoples R China
  • [ 9 ] [Zhu, Shitao]Fuzhou Univ, Coll Comp & Data Sci, Fuzhou 350116, Peoples R China

Reprint 's Address:

  • [Xu, Qin]Fujian Med Univ, Fujian Canc Hosp, Dept Gynecol, Clin Oncol Sch, Fuzhou 350011, Fujian, Peoples R China;;[Chen, Jihong]Fujian Med Univ, Fujian Canc Hosp, Clin Oncol Sch, Dept Radiat Oncol, Fuzhou, Peoples R China

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Source :

SCIENTIFIC REPORTS

ISSN: 2045-2322

Year: 2025

Issue: 1

Volume: 15

3 . 8 0 0

JCR@2023

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 0

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