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author：

Chen, L. (Chen, L..) [1] | Li, L. (Li, L..) [2] | Zhao, H. (Zhao, H..) [3] | Li, H. (Li, H..) [4] | Li, J. (Li, J..) [5] | Li, C. (Li, C..) [6] | Zhou, Y. (Zhou, Y..) [7] | Yang, L. (Yang, L..) [8] | Liang, J. (Liang, J..) [9] | Zhang, H. (Zhang, H..) [10] | Xu, P. (Xu, P..) [12] | Yuan, C. (Yuan, C..) [13] | Liu, Z. (Liu, Z..) [14] | Huang, M. (Huang, M..) [15] | Jiang, L. (Jiang, L..) [16]

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Scopus

Abstract：

Angiogenesis　provides　essential　nutrients　and　oxygen　to　tumors　during　tumorigenesis,　facilitating　invasion　and　metastasis.　Consequently,　inhibiting　tumor　angiogenesis　is　an　established　strategy　in　anti-cancer　therapy.　In　this　study,　we　engineered　a　dual-function　nanosystem　with　both　antiangiogenic　and　photodynamic　properties.　We　transformed　the　hydrophobic　photosensitizer　zinc　phthalocyanine　(PS)　into　a　hydrophilic　form　via　protein　renaturation,　resulting　in　a　novel　photosensitizer:　Monocyte-Activating　Polypeptide-II　(EMAP-II:PS@NPs).　Characterization　through　dynamic　light　scattering　(DLS)　and　UV–vis　spectroscopy　showed　that　these　nanoparticles　exhibited　uniform　size　and　stability,　and　enhanced　solubility.　We　further　demonstrated　that　EMAP-II:PS@NPs　effectively　target　tumor　vascular　endothelia　causing　intracellular　photodynamic　cytotoxicity.　Notably,　EMAP-II:PS@NPs　achieved　effective　ablation　of　solid　tumors　at　significantly　reduced　dosages　of　drugs　compared　to　conventional　therapies,　due　to　their　potent　apoptotic　effects　on　light-exposed　cells.　This　study　highlights　the　potential　of　combining　anti-angiogenic　activity　with　phototherapy,　paving　the　way　for　innovative　cancer　treatment　strategies.　©　2025　Elsevier　B.V.

Keyword：

Angiogenesis Anti-tumor EMAP-II Phthalocyanine

Community：

  • [ 1 ] [Chen L.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 2 ] [Li L.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 3 ] [Zhao H.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 4 ] [Li H.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 5 ] [Li J.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 6 ] [Li C.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 7 ] [Zhou Y.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 8 ] [Yang L.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 9 ] [Liang J.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 10 ] [Zhang H.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 11 ] [Li J.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 12 ] [Xu P.]College of Biological Science and Engineering, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 13 ] [Xu P.]The National & Local Joint Engineering Research Center on Biopharmaceutical and Photodynamic Therapy Technologies, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 14 ] [Yuan C.]College of Biological Science and Engineering, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 15 ] [Yuan C.]The National & Local Joint Engineering Research Center on Biopharmaceutical and Photodynamic Therapy Technologies, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 16 ] [Liu Z.]Department of Oncology, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Fujian, Fuzhou, 350001, China
  • [ 17 ] [Huang M.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 18 ] [Huang M.]The National & Local Joint Engineering Research Center on Biopharmaceutical and Photodynamic Therapy Technologies, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 19 ] [Jiang L.]College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
  • [ 20 ] [Jiang L.]The National & Local Joint Engineering Research Center on Biopharmaceutical and Photodynamic Therapy Technologies, Fuzhou University, Fujian, Fuzhou, 350116, China

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Colloids and Surfaces B: Biointerfaces

ISSN： 0927-7765

Year： 2025

Volume： 248

5 . 4 0 0

JCR@2023

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ESI Highly Cited Papers on the List： 0 Unfold All

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