Today,　cancer　has　become　one　of　the　leading　global　tragedies.　It　occurs　when　a　small　number　of　cells　in　the　body　mutate,　causing　some　of　them　to　evade　the　body＇s　immune　system　and　proliferate　uncontrollably.　Even　more　irritating　is　the　fact　that　patients　with　cancers　frequently　relapse　after　conventional　chemotherapy　and　radiotherapy,　leading　to　additional　suffering.　Scientists　thereby　presume　that　cancer　stem　cells　(CSCs)　are　the　underlying　cause　of　metastasis　and　recurrence.　In　recent　years,　it　was　shown　that　not　only　can　chemotherapy　and　radiotherapy　underperform　in　the　treatment　of　breast　cancer,　but　they　can　also　increase　the　number　of　breast　cancer　stem　cells　(BCSCs)　that　transform　regular　breast　cancer　cells　into　their　own　population.　Such　data　somewhat　support　the　aforementioned　hypothesis.　Meanwhile,　our　understanding　of　the　extracellular　matrix　(ECM)　has　changed　considerably　over　the　last　decade.　A　lot　of　studies　have　bit　by　bit　complemented　human　knowledge　regarding　how　the　ECM　greatly　shapes　the　behaviors　of　BCSCs.　In　this　review,　we　highlighted　the　influence　on　BCSCs　exerted　by　different　critical　components　and　biochemical　properties　of　ECM.