Given　the　rising　demand　for　cyclohexanol　in　the　nylon　industry　and　the　escalating　issues　of　high　production　costs　and　potential　environmental　harm　in　traditional　cyclohexanol　production,　developing　a　safe,　environmentally　friendly,　and　cost-effective　process　for　producing　cyclohexanol　from　cyclohexene　is　crucial.　In　addition,　the　different　composition　of　intermediates　will　significantly　affect　the　economy　of　each　reaction　unit.　Therefore,　this　study　proposed　a　novel　reactive　distillation　process　involving　esterification,　transesterification,　and　hydrolysis.　Three　reactive　distillation　processes　of　1000　t/a　capacity　of　cyclohexanol　production　with　different　purity　intermediates　were　designed　and　optimized　using　a　sequential　iterative　algorithm　to　minimize　the　total　annual　cost,　which　amounted　to　422116.65　$/a.　Furthermore,　the　energy　consumption　and　environmental　emissions　were　compared　after　optimization.　By　comparing　the　influence　of　various　purity　intermediates　on　each　process　unit,　it　was　qualitatively　determined　that　higher　purity　requirements　did　not　necessarily　yield　superior　results.　Finally,　to　quantify　the　influence　of　each　variable　on　economic　performance　of　whole　process,　response　surface　method　was　performed　using　central　composite　design　for　minimum　total　annual　cost　objectives　with　a　3.25　%　error　between　model　and　simulation.　This　study　aims　to　guide　the　development　of　a　comprehensive,　costeffective,　and　efficient　reactive　distillation　process　for　cyclohexanol　production.