Organophosphorus　compounds　are　extensively　utilized　in　the　field　of　medicine,　materials,　life　sciences,　and　organic　synthesis,　among　which　chiral　phosphorus　compounds　are　the　most　widely　used.　Therefore,　the　construction　of　chiral　phosphorus　centers　has　always　been　the　hotspot　and　challenge　in　organic　synthesis.　Traditional　synthesis　methods　are　mainly　focused　on　chiral　resolution　and　chiral　induction　strategies.　Recently,　the　construction　of　chiral　phosphorus　centers　via　asymmetric　catalysis　has　been　well　developed.　The　recently　development　of　desymmetrization　strategies　in　the　construction　of　phos-　phorus　centers　is　summarized,　mainly　focused　on　the　transformation　of　C—H,　C=C,　C≡C　bonds　and　hydroxyl　group.　What’s　more,　the　deficiencies　of　current　strategies　and　the　trends　of　future　development　have　also　been　discussed.　©　2024　Shanghai　Institute　of　Organic　Chemistry,　Chinese　Academy　of　Sciences.