Query：
学者姓名：宋秋玲
Refining：
Year
Type
Indexed by
Source
Complex
Former Name
Co-
Language
Clean All
Abstract ：
Chiral five-membered cyclic tertiary alcohols are important structural motifs in functional materials, pharmaceuticals, and bioactive molecules. Hence, developing efficient methodologies for synthesizing compounds featuring these privileged scaffolds represents a crucial pursuit within synthetic chemistry. Herein, we present a regio- and enantioselective Ni-catalyzed strategy for the reductive [3 + 2] annulation of beta-bromoenones with alkynes, providing convenient access to chiral five-membered cyclic tertiary alcohols with high levels of regio-, and enantioselectivity via axial chirality transfer to central chirality. The utilization of an environmentally sustainable bis(pinacolato)diboron (B(2)pin(2)) is crucial for the success of this asymmetric reductive cyclization reaction. Simultaneously, the mild reaction environment greatly enhances functional group compatibility. This has been demonstrated by the broad substrate scope, late-stage functionalizations of bioactive compounds or drug molecules, and subsequent transformations. Amongst, it is worth emphasizing that these functionally enriched chiral five-membered cyclic tertiary alcohols can efficiently participate in Diels-Alder reactions to synthesize enantioenriched polycyclic and heterocyclic molecules, thereby further validating the significance of introducing a cyclopentadiene skeleton. The preliminary mechanistic studies revealed the mode of action of B(2)pin(2) in mononuclear Ni-catalyzed asymmetric reductive [3 + 2] annulation reactions and density functional theory (DFT) calculations clarified the origin of the experimentally observed regio- and enantioselectivity.
Keyword ：
B(2)pin(2) as reductant B(2)pin(2) as reductant Chiral tertiary alcohols Chiral tertiary alcohols Enantioselectivity Enantioselectivity Nickel Nickel Reductive [3+2] annulation Reductive [3+2] annulation
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Li, Wangyang , Zheng, Yanping , Gu, Yunya et al. Bis(pinacolato)Diboron-Enabled Nickel-Catalyzed Regio- and Enantioselective Reductive [3+2] Annulation of β-Bromoenones with Alkynes [J]. | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2025 , 64 (24) . |
| MLA | Li, Wangyang et al. "Bis(pinacolato)Diboron-Enabled Nickel-Catalyzed Regio- and Enantioselective Reductive [3+2] Annulation of β-Bromoenones with Alkynes" . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 64 . 24 (2025) . |
| APA | Li, Wangyang , Zheng, Yanping , Gu, Yunya , Cheng, Shanshan , Xie, Jinhui , Lu, Yong et al. Bis(pinacolato)Diboron-Enabled Nickel-Catalyzed Regio- and Enantioselective Reductive [3+2] Annulation of β-Bromoenones with Alkynes . | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 2025 , 64 (24) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
In the past decades, chiral sp3-geminated bimetallic reagents based on B, Si, and Sn have drawn much attention due to their unique structure and the potential for iterative multifold transformations, thus efficiently increasing the molecular complexity. However, the asymmetric preparation of such reagents is highly challenging and new synthetic approaches are still in demand. This review provides a brief overview of the synthesis of nonracemic gem-borylstannyl, gem-borylsilyl, and gem-diboryl compounds, and is organized according to the types of gem-bimetallic reagents and their corresponding synthetic strategies.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Li, Xin , Song, Qiuling . Asymmetric synthesis of chiral sp3-geminated borylstannyl, borylsilyl, and diboryl compounds [J]. | ORGANIC CHEMISTRY FRONTIERS , 2025 , 12 (9) : 3129-3142 . |
| MLA | Li, Xin et al. "Asymmetric synthesis of chiral sp3-geminated borylstannyl, borylsilyl, and diboryl compounds" . | ORGANIC CHEMISTRY FRONTIERS 12 . 9 (2025) : 3129-3142 . |
| APA | Li, Xin , Song, Qiuling . Asymmetric synthesis of chiral sp3-geminated borylstannyl, borylsilyl, and diboryl compounds . | ORGANIC CHEMISTRY FRONTIERS , 2025 , 12 (9) , 3129-3142 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Although representing an atom- and step-economic access to aromatic nitrile-containing compounds, the denitrogenative transformations of 3-aminoindazoles are highly challenging due to high C-N bond dissociation energy, stable five-membered heterocycles, and selective cleavage of two C-N bonds in one step. Only in recent years have chemists addressed the reactivity and selectivity issues of this reaction. By virtue of which, a diverse array of structurally novel compounds have been synthesized in good yields. This chapter summarizes and discusses the recent advances in denitrogenative transformations of 3-aminoindazoles, which include coupling with conjugated unsaturated systems, coupling with thiols and diselenides, denitrogenative transannulation, and N-N bond cleavage of 3-aminoindazoles. © 2025 WILEY-VCH GmbH.
Keyword ：
3-Aminoindazoles 3-Aminoindazoles arenes arenes C-N bond cleavage C-N bond cleavage copper copper denitrogenation denitrogenation diselenides diselenides enamines enamines heterocycles heterocycles ketene dithioacetals ketene dithioacetals N-N bond cleavage N-N bond cleavage radical radical thiols thiols transannulation transannulation
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Li, X. , Song, Q. . Denitrogenative Transformations of 3-Aminoindazoles [未知]. |
| MLA | Li, X. et al. "Denitrogenative Transformations of 3-Aminoindazoles" [未知]. |
| APA | Li, X. , Song, Q. . Denitrogenative Transformations of 3-Aminoindazoles [未知]. |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Compared with well-developed radical aromatic ring migration, heteroatomic radical migration and alkenyl radical migration remain challenging. Herein, a photoinduced remote radical migration reaction based on the aromatic skeleton through tetracoordinate boron species has been developed. In this work, commercially available diboron reagent (B(2)pin(2)) or alkenyl boron (alkenylBpin) react with o-bromostyrenes as well as their analogues under the mediation of lithium reagents in a single-vessel reaction. This process undergoes an interesting 1,4-, 1,5- or 1,6-remote radical migration via intramolecular circular transition state, which introduces a large array of boron-migrative or alkenyl-migrative compounds. In particular, the 1,6-radical migration reaction has not been reported before. This protocol features readily accessible starting materials, high atom economy, broad substrate scope and diversified valuable products with Csp(3)-B and Csp(2)-B bonds obtained simultaneously with B(2)pin(2) or portrays alkenyl-migrative module and excellent E/Z selectivity with alkenylBpins. [GRAPHICS] .
Keyword ：
alkenyl radical migration alkenyl radical migration boryl radical migration boryl radical migration lithium reagent lithium reagent remote migration remote migration tetracoordinate boron species tetracoordinate boron species
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Li, Chaokun , Chen, Nan , Yao, Tangfeng et al. Remote Boryl and Alkenyl Radical Migration of Olefin-Bearing Aryl Bromides [J]. | CCS CHEMISTRY , 2025 , 7 (1) : 279-292 . |
| MLA | Li, Chaokun et al. "Remote Boryl and Alkenyl Radical Migration of Olefin-Bearing Aryl Bromides" . | CCS CHEMISTRY 7 . 1 (2025) : 279-292 . |
| APA | Li, Chaokun , Chen, Nan , Yao, Tangfeng , Zhao, Chenchen , Liao, Shangteng , Song, Qiuling . Remote Boryl and Alkenyl Radical Migration of Olefin-Bearing Aryl Bromides . | CCS CHEMISTRY , 2025 , 7 (1) , 279-292 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Domino cascade reactions, which can construct multiple bonds in one pot, are efficient methods to synthesize N-heterocycles and other useful skeletons. Herein, we report an expedient synthesis of polysubstituted benzo[b][1,5]naphthyridine via Mn(III)-mediated C-C bond cleavage of cyclopropanols. These reactions were initiated by addition of beta-carbonyl radicals, generated from cyclopropyl alcohols in the presence of Mn(III), to 2-(2-isocyanophenyl)acetonitriles to give quinolin-3-amines, which went through intramolecular cyclizations and dehydrogenation to give the final products.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Mu, Shiqiang , Xuan, Qingqing , Luo, Ying et al. Synthesis of Polysubstituted Benzo[b][1,5]naphthyridine via Mn(III)-Mediated Domino Cascade Reactions of Cyclopropanols and 2-(2-Isocyanophenyl)acetonitriles [J]. | ORGANIC LETTERS , 2025 , 27 (1) : 153-158 . |
| MLA | Mu, Shiqiang et al. "Synthesis of Polysubstituted Benzo[b][1,5]naphthyridine via Mn(III)-Mediated Domino Cascade Reactions of Cyclopropanols and 2-(2-Isocyanophenyl)acetonitriles" . | ORGANIC LETTERS 27 . 1 (2025) : 153-158 . |
| APA | Mu, Shiqiang , Xuan, Qingqing , Luo, Ying , Guo, Yu , Xu, Jian , Song, Qiuling . Synthesis of Polysubstituted Benzo[b][1,5]naphthyridine via Mn(III)-Mediated Domino Cascade Reactions of Cyclopropanols and 2-(2-Isocyanophenyl)acetonitriles . | ORGANIC LETTERS , 2025 , 27 (1) , 153-158 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
The synthesis of polycyclic indoles is significant in organic chemistry, due to such heterocyclic frameworks being present in numerous bioactive pharmaceuticals and natural alkaloids. Herein, we provide an efficient radical cascade cyclization strategy to generate indole-fused diazepine derivatives using phosphoryl or sulfonyl radicals with N-(2-(1H-indol-1-yl)phenyl)-N-methylmethacrylamides. The merits of this synthesis are attributed to its accessible starting materials, broad substrate compatibility and excellent diastereoselectivity.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Wang, Yutong , Huang, Xiujuan , Chen, Jinglong et al. Diastereoselective radical cascade cyclization to access indole-fused diazepine derivatives [J]. | ORGANIC & BIOMOLECULAR CHEMISTRY , 2025 , 23 (18) : 4349-4354 . |
| MLA | Wang, Yutong et al. "Diastereoselective radical cascade cyclization to access indole-fused diazepine derivatives" . | ORGANIC & BIOMOLECULAR CHEMISTRY 23 . 18 (2025) : 4349-4354 . |
| APA | Wang, Yutong , Huang, Xiujuan , Chen, Jinglong , Xu, Jian , Song, Qiuling . Diastereoselective radical cascade cyclization to access indole-fused diazepine derivatives . | ORGANIC & BIOMOLECULAR CHEMISTRY , 2025 , 23 (18) , 4349-4354 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
1,2-Difunctionalization of alkynes offers a straightforward approach to access polysubstituted alkenes. However, simultaneous multi-component cascade transformations including difunctionalization of two alkynes with both syn- and anti-selectivity in one catalyst system is undeveloped and proves to be a significant challenge. Herein, we report a Nickel-catalyzed four-component reaction to access polysubstituted 1,3-dienes using two terminal alkynes, aryl boroxines, and perfluoroalkyl iodides, wherein the reaction forms three new C-C bonds in a single vessel and serve as a modular strategy to access polysubstituted 1,3-dienes with excellent chemoselectivity, good regioselectivity and exclusive stereoselectivity. Control experiments reveal the plausible reaction mechanism and DFT calculations explain the cause for the formation of this unusual four-component reaction. Furthermore, we successfully incorporate two biologically active units into 1,2,3,4-tetrasubstituted 1,3-dienes, which greatly increases the diversity of molecular scaffolds and brings more potential values to medicinal chemistry, the synthetic utility of our protocol is further demonstrated by the late-stage transformations. Multi-component cascade transformations including difunctionalization of two alkynes with both syn- and anti-selectivity in one catalyst system is challenging. Herein, the authors report a Nickel-catalyzed four-component reaction to access densely substituted 1,3-dienes using two terminal alkynes, aryl boroxines, and perfluoroalkyl iodides.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Chen, Shanglin , Wang, Ya-Nan , Xie, Jinhui et al. Chemo-, regio- and stereoselective access to polysubstituted 1,3-dienes via Nickel-catalyzed four-component reactions [J]. | NATURE COMMUNICATIONS , 2024 , 15 (1) . |
| MLA | Chen, Shanglin et al. "Chemo-, regio- and stereoselective access to polysubstituted 1,3-dienes via Nickel-catalyzed four-component reactions" . | NATURE COMMUNICATIONS 15 . 1 (2024) . |
| APA | Chen, Shanglin , Wang, Ya-Nan , Xie, Jinhui , Li, Wangyang , Ye, Mingxing , Ma, Xingxing et al. Chemo-, regio- and stereoselective access to polysubstituted 1,3-dienes via Nickel-catalyzed four-component reactions . | NATURE COMMUNICATIONS , 2024 , 15 (1) . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Herein, we report an expedient synthesis of fused phosphorus-containing heterocycles via Rh-catalyzed cascade C-H activation, alkyne insertion, and lactonization reactions. The substrate scope and the group tolerance are good, as various substituted benzoic acids, N-methoxybenzamides, and 2-phenylindoles could go through the reactions smoothly to afford the corresponding products in moderate to high yields. Additionally, excellent regioselectivities are shown in the alkyne insertion with the assistance of an electron-withdrawing phosphonate group.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Yang, Yingying , Chen, Menghan , Xuan, Qingqing et al. Rh(III)-Catalyzed Regioselective Alkyne Insertion in the Context of C-H Activation and Lactonization Reactions: Synthesis of Fused 1,2-Oxaphospholenes [J]. | ORGANIC LETTERS , 2024 , 26 (36) : 7683-7687 . |
| MLA | Yang, Yingying et al. "Rh(III)-Catalyzed Regioselective Alkyne Insertion in the Context of C-H Activation and Lactonization Reactions: Synthesis of Fused 1,2-Oxaphospholenes" . | ORGANIC LETTERS 26 . 36 (2024) : 7683-7687 . |
| APA | Yang, Yingying , Chen, Menghan , Xuan, Qingqing , Xu, Jian , Song, Qiuling . Rh(III)-Catalyzed Regioselective Alkyne Insertion in the Context of C-H Activation and Lactonization Reactions: Synthesis of Fused 1,2-Oxaphospholenes . | ORGANIC LETTERS , 2024 , 26 (36) , 7683-7687 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Organophosphines and sulfones have a wide range of applications and they are prevalent in bioactive molecules as well as pharmaceutical compounds. Numerous strategies have been developed to synthesize them in modern synthetic chemistry. However, compared with transition metal-catalyzed strategies and photocatalysis-promoted methods, the transition metal-free protocols are elusive and have been less reported. Herein we report a difluorocarbene-enabled deaminative phosphonylation and sulfonylation reaction. Various allylic diphenylphosphine oxides and allylic sulfones could be obtained smoothly from the corresponding benzylic tertiary amines in moderate to high yields via this method. A deaminative functionalization of aliphatic tertiary amines via the cleavage of C(sp3)-N bonds under transition metal-free conditions was disclosed, which goes through SN2 reaction with various phosphorus and sulfur nucleophiles.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Li, Chengbo , Guo, Yu , Su, Jianke et al. Expedient deaminative phosphorylation and sulfonylation of benzylic tertiary amines enabled by difluorocarbene [J]. | ORGANIC CHEMISTRY FRONTIERS , 2024 , 11 (11) : 3179-3185 . |
| MLA | Li, Chengbo et al. "Expedient deaminative phosphorylation and sulfonylation of benzylic tertiary amines enabled by difluorocarbene" . | ORGANIC CHEMISTRY FRONTIERS 11 . 11 (2024) : 3179-3185 . |
| APA | Li, Chengbo , Guo, Yu , Su, Jianke , Hu, Xinyuan , Xuan, Qingqing , Song, Qiuling . Expedient deaminative phosphorylation and sulfonylation of benzylic tertiary amines enabled by difluorocarbene . | ORGANIC CHEMISTRY FRONTIERS , 2024 , 11 (11) , 3179-3185 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Abstract ：
Herein, we report a ligand-controlled palladium-catalyzed method that enables the synthesis of ynones and gamma-butenolides with excellent regioselectivity from the same set of readily available aryl iodides, aryl acetylenes, and BrCF2CO2K. In this reaction, the [Pd-II]CF2 does demonstrate electrophilicity and can generate CO readily when reacting with H2O. It is environmentally friendly and safe compared to traditional methods, and the current protocol enables us to afford ynones and gamma-butenolides in high yields with excellent functionality tolerance. Moreover, esters can also be obtained with corresponding phenols and alcohols utilizing this strategy. The success of late-stage functionalization of bioactive compounds further illustrates the synthetic utility of this protocol in material development and drug discovery.
Cite：
Copy from the list or Export to your reference management。
| GB/T 7714 | Sheng, Heyun , Chen, Zhiwei , Song, Qiuling . Palladium-Catalyzed Difluorocarbene Transfer Enabled Divergent Synthesis of γ-Butenolides and Ynones from Iodobenzene and Terminal Alkynes [J]. | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 2024 , 146 (2) : 1722-1731 . |
| MLA | Sheng, Heyun et al. "Palladium-Catalyzed Difluorocarbene Transfer Enabled Divergent Synthesis of γ-Butenolides and Ynones from Iodobenzene and Terminal Alkynes" . | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 146 . 2 (2024) : 1722-1731 . |
| APA | Sheng, Heyun , Chen, Zhiwei , Song, Qiuling . Palladium-Catalyzed Difluorocarbene Transfer Enabled Divergent Synthesis of γ-Butenolides and Ynones from Iodobenzene and Terminal Alkynes . | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 2024 , 146 (2) , 1722-1731 . |
| Export to | NoteExpress RIS BibTex |
Version ：
Export
| Results： |
Selected to |
| Format： |
