Angiogenesis　provides　essential　nutrients　and　oxygen　to　tumors　during　tumorigenesis,　facilitating　invasion　and　metastasis.　Consequently,　inhibiting　tumor　angiogenesis　is　an　established　strategy　in　anti-cancer　therapy.　In　this　study,　we　engineered　a　dual-function　nanosystem　with　both　antiangiogenic　and　photodynamic　properties.　We　transformed　the　hydrophobic　photosensitizer　zinc　phthalocyanine　(PS)　into　a　hydrophilic　form　via　protein　renaturation,　resulting　in　a　novel　photosensitizer:　Monocyte-Activating　Polypeptide-II　(EMAP-II:PS@NPs).　Characterization　through　dynamic　light　scattering　(DLS)　and　UV–vis　spectroscopy　showed　that　these　nanoparticles　exhibited　uniform　size　and　stability,　and　enhanced　solubility.　We　further　demonstrated　that　EMAP-II:PS@NPs　effectively　target　tumor　vascular　endothelia　causing　intracellular　photodynamic　cytotoxicity.　Notably,　EMAP-II:PS@NPs　achieved　effective　ablation　of　solid　tumors　at　significantly　reduced　dosages　of　drugs　compared　to　conventional　therapies,　due　to　their　potent　apoptotic　effects　on　light-exposed　cells.　This　study　highlights　the　potential　of　combining　anti-angiogenic　activity　with　phototherapy,　paving　the　way　for　innovative　cancer　treatment　strategies.　©　2025　Elsevier　B.V.