Transition　metal　sulfides　are　emerging　as　promising　anode　materials　for　sodium-ion　batteries　(SIBs)　due　to　their　high　theoretical　capacity　and　low　cost,　their　practical　application　yet　face　critical　issues　of　sluggish　kinetics　and　poor　cycling　stability.　In　this　study,　a　reliable　approach　is　introduced　to　overcome　these　challenges　by　fabrication　of　Se0.75-Fe1-xS0.25@SC　hollow　nanospheres　thanks　to　the　enriched　robust　Fe─S─C,　C─S,　and　C─Se　bonding,　which　greatly　benefit　for　enhancing　both　reaction　kinetics　and　structural　stability.　Kinetic　study　combining　with　in　situ　characterization　reveals　that　the　incorporation　of　rich-Se　into　FeSx　induces　the　formation　of　cationic　Fe　and　Se　vacancies,　leading　to　abundant　sites　and　optimized　path　for　sodium　storage.　Density　functional　theory　calculations　also　demonstrate　how　Se-rich　engineering　weakens　carbonaceous　polar　C─S─Fe　bonds　and　accelerates　reaction　dynamics.　The　as-prepared　Se0.75-Fe1-xS0.25@SC　can　deliver　a　high　reversible　capacity　of　515 mAh g−1　at　2 A g−1　over　1250　cycles　and　achieve　superior　rate　capability　with　maintaining　capacity　of　418 mAh g−1　at　10 A g−1.　This　work　pioneers　the　concept　of　vacancy-rich　functionalized　nanostructures,　offering　a　new　pathway　for　designing　advanced　electrode　materials　for　energy　storage　devices.　©　2024　Wiley-VCH　GmbH.