In　this　study,　we　report　a　sustainable,　visible　light　and　heterogeneous　photocatalytic　system　to　address　these　issues,　using　the　ternary　sulfide　ZnIn2S4　(ZIS)　as　a　photoredox　catalyst.　Our　protocol　uses　visible　light　irradiation　to　activate　the　photoredox　catalyst,　generating　acyl　radicals　from　aldehydes.　The　methodology　demonstrated　a　broad　substrate　scope　and　commendable　recyclability.　The　method　also　proved　capable　of　scaling　to　the　gram　level　while　maintaining　high　efficiency,　thus　highlighting　the　robustness　and　reusability　of　ZIS.　This　work　not　only　proposes　a　novel　method　for　the　heterogeneous　photocatalytic　Minisci-type　alkylation　reaction,　but　also　contributes　a　valuable　approach　towards　enhancing　the　efficacy　and　sustainability　of　photocatalysts　within　the　pharmaceutical　industry.　©　2024　Fudan　University