In　situ　disc　regeneration　is　a　meticulously　orchestrated　process,　which　involves　cell　recruitment,　proliferation　and　differentiation　within　a　local　inflammatory　niche.　Thus　far,　it　remains　a　challenge　to　establish　a　multi-staged　regulatory　framework　for　coordinating　these　cellular　events,　therefore　leading　to　unsatisfactory　outcome.　This　study　constructs　a　super　paramagnetically-responsive　cellular　gel,　incorporating　superparamagnetic　iron　oxide　nanoparticles　(SPIONs)　and　aptamer-modified　palladium-hydrogen　nanozymes　(PdH-Apt)　into　a　double-network　polyacrylamide/hyaluronic　acid　(PAAm/HA)　hydrogel.　The　Aptamer　DB67　within　magnetic　hydrogel　(Mag-gel)　showed　a　high　affinity　for　disialoganglioside　(GD2),　a　specific　membrane　ligand　of　nucleus　pulposus　stem　cells　(NPSCs),　to　precisely　recruit　them　to　the　injury　site.　The　Mag-gel　exhibits　remarkable　sensitivity　to　a　magnetic　field　(MF),　which　exerts　tunable　micro/nano-scale　forces　on　recruited　NPSCs　and　triggers　cytoskeletal　remodeling,　consequently　boosting　cell　expansion　in　the　early　stage.　By　altering　the　parameters　of　MF,　the　mechanical　cues　within　the　hydrogel　facilitates　differentiation　of　NPSCs　into　nucleus　pulposus　cells　to　restore　disc　structure　in　the　later　stage.　Furthermore,　the　PdH　nanozymes　within　the　Mag-gel　mitigate　the　harsh　inflammatory　microenvironment,　favoring　cell　survival　and　disc　regeneration.　This　study　presents　a　remote　and　multi-staged　strategy　for　chronologically　regulating　endogenous　stem　cell　fate,　supporting　disc　regeneration　without　invasive　procedures.　©　2024　The　Author(s).　Advanced　Science　published　by　Wiley-VCH　GmbH.