Pd-Catalyzed B-H Aryl/Alkenylation of 1,2-Azaborines - Details

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Abstract：

Direct　functionalization　of　1,2-azaborines　to　construct　B-C　bonds　remains　challenging.　Here,　we　report　a　Pd-catalyzed　B-H　aryl/alkenylation　reaction　of　1,2-azaborines.　The　method　provides　a　general　platform　to　access　diverse　boron-substituted　1,2-azaborine　compounds　(＞60　examples).　The　synthetic　utility　is　highlighted　through　the　late-stage　modification　of　bioactive　molecules,　as　well　as　the　preparation　and　transformations　of　the　B-10-enriched　1,2-azaborine　product　and　the　synthesis　of　four　BN　isostere　analogues　of　bioactive　molecules.　And　the　reaction　mechanism　is　also　explored　and　discussed.

Keyword：

1,2-azaborines B-H aryl/alkenylation B-Hbond transformation mechanistic studies palladium catalysis

Community：

[ 1 ] [Zhang, Zhen]Fuzhou Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fuzhou 350108, Fujian, Peoples R China
[ 2 ] [Su, Peiwen]Fuzhou Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fuzhou 350108, Fujian, Peoples R China
[ 3 ] [Yang, Kai]Fuzhou Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fuzhou 350108, Fujian, Peoples R China
[ 4 ] [Song, Qiuling]Fuzhou Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fuzhou 350108, Fujian, Peoples R China
[ 5 ] [Jiang, Dandan]Southern Univ Sci & Technol, Dept Chem, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Guangdong, Peoples R China
[ 6 ] [Yu, Peiyuan]Southern Univ Sci & Technol, Dept Chem, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Guangdong, Peoples R China
[ 7 ] [Jiang, Dandan]Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Guangdong, Peoples R China
[ 8 ] [Yu, Peiyuan]Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Guangdong, Peoples R China
[ 9 ] [Song, Qiuling]Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China

Reprint 's Address：

[Yang, Kai]Fuzhou Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fuzhou 350108, Fujian, Peoples R China;;[Song, Qiuling]Fuzhou Univ, Coll Chem, Key Lab Mol Synth & Funct Discovery, Fuzhou 350108, Fujian, Peoples R China;;[Yu, Peiyuan]Southern Univ Sci & Technol, Dept Chem, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Guangdong, Peoples R China;;[Yu, Peiyuan]Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Guangdong, Peoples R China;;[Song, Qiuling]Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China;;

Email：

kyang@fzu.edu.cn |
yupy@sustech.edu.cn |
qsong@fzu.edu.cn

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