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author:

Xu, Yang (Xu, Yang.) [1] | Guo, Cuixia (Guo, Cuixia.) [2] (Scholars:郭翠霞) | Zhou, Chongqi (Zhou, Chongqi.) [3] | He, Yonghong (He, Yonghong.) [4] | Cao, Ke (Cao, Ke.) [5] | Li, Defa (Li, Defa.) [6]

Indexed by:

EI Scopus SCIE

Abstract:

This study addresses the critical need for high purity chiral molecules in biological systems by overcoming the challenges associated with the quantitative detection of chiral molecules and their enantiomeric mixtures. We developed an innovative detection approach that leverages the two-dimensional information gleaned from natural optical rotation (NOR) and Faraday optical rotation (FOR) under magnetic fields in chiral molecules, combined with an ultrahigh-resolution weak measurement sensor. This novel weak measurement system achieves unparalleled accuracy in detecting spin angles, with a precision of 1.86 x 10(-5 degrees). Notably, our method introduces no chemical reactions or interference with the substances under test. It offers enhanced discrimination capabilities through the dual-dimensional analysis of both natural and Faraday optical rotation, alongside a simple and compact sensor design. Conclusively, our study introduces a novel, high-precision, and multi-dimensional optical detection paradigm for chiral molecules. By incorporating Faraday rotation in the presence of a magnetic field, we expand the informational dimensionality accessible to the original weak measurement sensor, facilitating the quantitative analysis of chiral molecules and their enantiomers. This breakthrough not only furnishes a novel instrument for the exploration and development of chiral pharmaceuticals but also propels the advancement of weak measurement sensing technology forward.

Keyword:

Chiral molecule Faraday effect Optical rotation Two-dimensional information Weak measurement

Community:

  • [ 1 ] [Xu, Yang]Shenzhen Childrens Hosp, Dept Lab Med, Shenzhen 518038, Peoples R China
  • [ 2 ] [Cao, Ke]Shenzhen Childrens Hosp, Dept Lab Med, Shenzhen 518038, Peoples R China
  • [ 3 ] [Li, Defa]Shenzhen Childrens Hosp, Dept Lab Med, Shenzhen 518038, Peoples R China
  • [ 4 ] [Guo, Cuixia]Fuzhou Univ, Sch Mech Engn & Automat, Fuzhou 350108, Peoples R China
  • [ 5 ] [Zhou, Chongqi]Tsinghua Univ, Inst Opt Imaging & Sensing, Shenzhen Key Lab Minimal Invas Med Technol, Tsinghua Shenzhen Int Grad Sch, Shenzhen 518055, Peoples R China
  • [ 6 ] [He, Yonghong]Tsinghua Univ, Inst Opt Imaging & Sensing, Shenzhen Key Lab Minimal Invas Med Technol, Tsinghua Shenzhen Int Grad Sch, Shenzhen 518055, Peoples R China
  • [ 7 ] [Zhou, Chongqi]Tsinghua Univ, Inst Biopharmaceut & Hlth Engn, Tsinghua Shenzhen Int Grad Sch, Shenzhen 518055, Peoples R China
  • [ 8 ] [He, Yonghong]Tsinghua Univ, Inst Biopharmaceut & Hlth Engn, Tsinghua Shenzhen Int Grad Sch, Shenzhen 518055, Peoples R China

Reprint 's Address:

  • [Cao, Ke]Shenzhen Childrens Hosp, Dept Lab Med, Shenzhen 518038, Peoples R China;;[Li, Defa]Shenzhen Childrens Hosp, Dept Lab Med, Shenzhen 518038, Peoples R China;;

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Source :

TALANTA

ISSN: 0039-9140

Year: 2024

Volume: 281

5 . 6 0 0

JCR@2023

Cited Count:

WoS CC Cited Count: 1

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

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