This　study　addresses　the　critical　need　for　high　purity　chiral　molecules　in　biological　systems　by　overcoming　the　challenges　associated　with　the　quantitative　detection　of　chiral　molecules　and　their　enantiomeric　mixtures.　We　developed　an　innovative　detection　approach　that　leverages　the　two-dimensional　information　gleaned　from　natural　optical　rotation　(NOR)　and　Faraday　optical　rotation　(FOR)　under　magnetic　fields　in　chiral　molecules,　combined　with　an　ultrahigh-resolution　weak　measurement　sensor.　This　novel　weak　measurement　system　achieves　unparalleled　accuracy　in　detecting　spin　angles,　with　a　precision　of　1.86　×　10−5°.　Notably,　our　method　introduces　no　chemical　reactions　or　interference　with　the　substances　under　test.　It　offers　enhanced　discrimination　capabilities　through　the　dual-dimensional　analysis　of　both　natural　and　Faraday　optical　rotation,　alongside　a　simple　and　compact　sensor　design.　Conclusively,　our　study　introduces　a　novel,　high-precision,　and　multi-dimensional　optical　detection　paradigm　for　chiral　molecules.　By　incorporating　Faraday　rotation　in　the　presence　of　a　magnetic　field,　we　expand　the　informational　dimensionality　accessible　to　the　original　weak　measurement　sensor,　facilitating　the　quantitative　analysis　of　chiral　molecules　and　their　enantiomers.　This　breakthrough　not　only　furnishes　a　novel　instrument　for　the　exploration　and　development　of　chiral　pharmaceuticals　but　also　propels　the　advancement　of　weak　measurement　sensing　technology　forward.　©　2024