Early　intervention　in　acute　myocardial　infarction　can　minimize　myocardial　damage　and　improve　patient　survival.　Herein,　a　low-cost　device-free　portable　immunobiosensing　platform　for　flexible　monitoring　of　immediate　myocardial　infarction　is　reported.　CuS-Pt　nanofragments　(CuS-Pt　NFs)　with　high　photothermal　conversion　efficiency　(approximate　to　26.41%)　are　synthesized　by　liquid-phase　polarity-mediated　synthesis.　The　CuS　NFs　are　loaded　in　situ　with　platinum　(Pt)　nanoreactors　using　a　solvothermal　reduction　strategy,　which　is　employed　to　enhance　the　efficiency　of　gas　production.　The　resulting　CuS-Pt　nanocatalysts　are　encapsulated　within　liposomes　for　signal　cascade　amplification.　Specifically,　cardiac　troponin　I　(cTn　I),　a　target　biomarker　in　serum,　is　captured　on　pre-modified　microtiter　plates　and　formed　into　a　classical　sandwich　model.　The　thermo-chemically　kinetically　enhanced　CuS-Pt　reactor　is　released　through　a　one-step　chemical　treatment　and　transferred　to　a　closed　gas　generator.　Under　the　excitation　of　a　near-infrared　laser　emitter,　the　internal　pressure　in　the　gas　generator　device　increases　with　time　and　drives　the　carbon　quantum　dot　solution　in　the　connected　hose.　The　moving　distance　shows　a　correlation　with　the　target　concentration.　This　work　provides　a　new　implementation　for　the　development　of　low-cost,　efficient　pressure　immunosensors　without　the　requirement　of　a　readout　device.　A　low-cost　device-free　portable　immunobiosensing　platform　is　designed　for　flexible　monitoring　of　immediate　myocardial　infarction　through　CuS-Pt　nanofragments　with　high　photothermal　conversion　efficiency.　The　thermo-chemically　kinetically　enhanced　CuS-Pt　reactor　is　released　by　a　one-step　chemical　treatment　and　transferred　to　a　closed　gas　generator　under　near-infrared　laser　illustration.　image