Multifunctional Biomimetic Nanocarriers for Dual-Targeted Immuno-Gene Therapy Against Hepatocellular Carcinoma - Details

author：

Indexed by：

EI

Abstract：

Growing　evidences　have　proved　that　tumors　evade　recognition　and　attack　by　the　immune　system　through　immune　escape　mechanisms,　and　PDL1/Pbrm1　genes　have　a　strong　correlation　with　poor　response　or　resistance　to　immune　checkpoint　blockade　(ICB)　therapy.　Herein,　a　multifunctional　biomimetic　nanocarrier　(siRNA-CaP@PD1-NVs)　is　developed,　which　can　not　only　enhance　the　cytotoxic　activity　of　immune　cells　by　blocking　PD1/PDL1　axis,　but　also　reduce　tumor　immune　escape　via　Pbrm1/PDL1　gene　silencing,　leading　to　a　significant　improvement　in　tumor　immunosuppressive　microenvironment.　Consequently,　the　nanocarrier　promotes　DC　cell　maturation,　enhances　the　infiltration　and　activity　of　CD8+　T　cells,　and　forms　long-term　immune　memory,　which　can　effectively　inhibit　tumor　growth　or　even　eliminate　tumors,　and　prevent　tumor　recurrence　and　metastasis.　Overall,　this　study　presents　a　powerful　strategy　for　co-delivery　of　siRNA　drugs,　immune　adjuvant,　and　immune　checkpoint　inhibitors,　and　holds　great　promise　for　improving　the　effectiveness　and　safety　of　current　immunotherapy　regimens.　©　2024　The　Author(s).　Advanced　Science　published　by　Wiley-VCH　GmbH.

Keyword：

Biomimetics Gene therapy Tumors

Community：

[ 1 ] [Sun, Yupeng]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
[ 2 ] [Sun, Yupeng]Mengchao Med-X Center, Fuzhou University, Fuzhou; 350116, China
[ 3 ] [Liu, Yan]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
[ 4 ] [Liu, Yan]College of Biological Science and Engineering, Fuzhou University, Fuzhou; 350116, China
[ 5 ] [Li, Rui]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
[ 6 ] [Li, Rui]College of Biological Science and Engineering, Fuzhou University, Fuzhou; 350116, China
[ 7 ] [Zhang, Cuilin]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
[ 8 ] [Zhang, Cuilin]Mengchao Med-X Center, Fuzhou University, Fuzhou; 350116, China
[ 9 ] [Wu, Ming]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
[ 10 ] [Wu, Ming]Mengchao Med-X Center, Fuzhou University, Fuzhou; 350116, China
[ 11 ] [Zhang, Xiaolong]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
[ 12 ] [Zhang, Xiaolong]Mengchao Med-X Center, Fuzhou University, Fuzhou; 350116, China
[ 13 ] [Zheng, Aixian]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
[ 14 ] [Zheng, Aixian]Mengchao Med-X Center, Fuzhou University, Fuzhou; 350116, China
[ 15 ] [Liao, Naishun]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
[ 16 ] [Zheng, Youshi]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
[ 17 ] [Xu, Haipo]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
[ 18 ] [Zeng, Rui]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
[ 19 ] [Zeng, Rui]Mengchao Med-X Center, Fuzhou University, Fuzhou; 350116, China
[ 20 ] [Zeng, Yongyi]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
[ 21 ] [Zeng, Yongyi]Mengchao Med-X Center, Fuzhou University, Fuzhou; 350116, China
[ 22 ] [Zeng, Yongyi]Liver Disease Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou; 350005, China
[ 23 ] [Liu, Xiaolong]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou; 350025, China
[ 24 ] [Liu, Xiaolong]Mengchao Med-X Center, Fuzhou University, Fuzhou; 350116, China
[ 25 ] [Liu, Xiaolong]CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences, Fuzhou; 350002, China

Reprint 's Address：

Email：

Related Keywords：

The effect of collagen mimetic peptides on L929 cells adhesion
2012，Journal of Functional Materials
An efficient human-following method by fusing kernelized correlation filter and depth information for mobile robot
2019，2019 IEEE International Conference on Robotics and Biomimetics, ROBIO 2019
Predict Robot Grasp Outcomes based on Multi-Modal Information
2018，2018 IEEE International Conference on Robotics and Biomimetics, ROBIO 2018
Teleoperation of multiple cooperative slave manipulators using graph-based non-singular terminal sliding-mode control
2017，2017 IEEE International Conference on Robotics and Biomimetics, ROBIO 2017
Dynamic objects detection and tracking for a laser scanner and camera system
2017，2017 IEEE International Conference on Robotics and Biomimetics, ROBIO 2017

Type
Departments

All Years Choose Year From to